Prof. Dr. Frank Hahn

2024

Rydzek, Simon; Guth, Florian; Friedrich, Steffen; Noske, Jakob; Höcker, Birte; Hahn, Frank
Chemoenzymatic Synthesis of Plant‐Derived Kavalactone Natural Products by Dynamic Resolution Us ...
In: ChemCatChem (2024)
doi:10.1002/cctc.202400883 ...

Roß-Taschner, Theresa; Derra, Sebastian; Stang, Jörg; Schlotte, Luca; Putratama, Anthony; Hahn, Frank
Highly Stereoselective Biocatalytic One-Pot Synthesis of Chiral Saturated Oxygen Heterocycles b ...
In: ACS Catalysis Bd. 14 (2024) . - S. 13420-13428
doi:10.1021/acscatal.4c03692 ...

Derra, Sebastian; Hoffmann, Julia; Hahn, Frank
Synthesis of Biomimetic Thioesters for Studies of Ketoreductase Domains from the Biosynthesis o ...
In: Synlett Bd. 35 (2024) Heft 14. - S. 1707-1712
doi:10.1055/a-2216-4521 ...

2023

Guth, Florian; Lindner, Frederick; Rydzek, Simon; Peil, Andreas; Friedrich, Steffen; Hauer, Bernhard; Hahn, Frank
Rieske Oxygenase-Catalyzed Oxidative Late-Stage Functionalization during Complex Antifungal Pol ...
In: ACS Chemical Biology Bd. 18 (2023) Heft 12. - S. 2450-2456
doi:10.1021/acschembio.3c00498 ...

Derra, Sebastian; Schlotte, Luca; Hahn, Frank
Suzuki–Miyaura Reaction in the Presence of N-Acetylcysteamine Thioesters Enables Rapid Synthesi ...
In: Chemistry Bd. 5 (2023) Heft 2. - S. 1407-1418
doi:10.3390/chemistry5020096 ...

2022

Schröder, Marius; Roß, Theresa; Hemmerling, Franziska; Hahn, Frank
Studying a bottleneck of multimodular polyketide synthase processing : the polyketide structure ...
In: ACS Chemical Biology Bd. 17 (2022) Heft 5. - S. 1030-1037
doi:10.1021/acschembio.2c00047 ...

Wagner, Lisa Maria Carolin; Stang, Jörg; Derra, Sebastian; Hollmann, Tim; Hahn, Frank
Towards understanding oxygen heterocycle-forming biocatalysts : a selectivity study of the pyra ...
In: Organic & Biomolecular Chemistry Bd. 20 (2022) Heft 48. - S. 9645-9649
doi:10.1039/D2OB02064E ...

2021

Wagner, Lisa Maria Carolin; Roß, Theresa; Hollmann, Tim; Hahn, Frank
Cross-linking of a polyketide synthase domain leads to a recyclable biocatalyst for chiral oxyg ...
In: RSC Advances Bd. 11 (2021) Heft 33. - S. 20248-20251
doi:10.1039/D1RA03692K ...

2020

Hahn, Frank; Guth, Florian
The ambruticins and jerangolids : chemistry, biology and chemoenzymatic synthesis of potent ant ...
In: Natural Product Reports Bd. 37 (2020) Heft 10. - S. 1300-1315
doi:10.1039/D0NP00012D ...

Hollmann, Tim; Berkhan, Gesche; Wagner, Lisa; Sung, Kwang Hoon; Kolb, Simon; Geise, Hendrik; Hahn, Frank
Biocatalysts from Biosynthetic Pathways : Enabling Stereoselective, Enzymatic Cycloether Format ...
In: ACS Catalysis Bd. 10 (2020) . - S. 4973-4982
doi:10.1021/acscatal.9b05071 ...

Wunderlich, Johannes; Roß, Theresa; Schröder, Marius; Hahn, Frank
Step-Economic Synthesis of Biomimetic β-Ketopolyene Thioesters and Demonstration of Their Usefu ...
In: Organic Letters Bd. 22 (2020) Heft 13. - S. 4955-4959
doi:10.1021/acs.orglett.0c01348 ...

2018

Hahn, Frank
Heterocycle biosynthesis via C-H functionalization
In: Nature Catalysis Bd. 1 (2018) . - S. 905-906
doi:10.1038/s41929-018-0194-2 ...

Sung, Kwang Hoon; Berkhan, Gesche; Hollmann, Tim; Wagner, Lisa Maria Carolin; Blankenfeldt, Wulf; Hahn, Frank
Insights into the Dual Activity of a Bifunctional Dehydratase-Cyclase Domain
In: Angewandte Chemie International Edition Bd. 57 (2018) Heft 1. - S. 343-347
doi:10.1002/anie.201707774 ...

Lindner, Frederick; Friedrich, Steffen; Hahn, Frank
Total Synthesis of Complex Biosynthetic Late-Stage Intermediates and Bioconversion by a Tailori ...
In: The Journal of Organic Chemistry Bd. 83 (2018) Heft 22. - S. 14091-14101
doi:10.1021/acs.joc.8b02047 ...

Hemmerling, Franziska; Lebe, Karen E.; Wunderlich, Johannes; Hahn, Frank
An Unusual Fatty Acyl:Adenylate Ligase (FAAL)–Acyl Carrier Protein (ACP) Didomain in Ambruticin ...
In: ChemBioChem Bd. 19 (2018) Heft 10. - S. 1006-1011
doi:10.1002/cbic.201800084 ...

2016

Hemmerling, Franziska; Hahn, Frank
Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides
In: Beilstein Journal of Organic Chemistry Bd. 12 (2016) . - S. 1512-1550
doi:10.3762/bjoc.12.148 ...

Friedrich, Steffen; Hemmerling, Franziska; Lindner, Frederick; Warnke, Anna; Wunderlich, Johannes; Berkhan, Gesche; Hahn, Frank
Characterisation of the Broadly-Specific O-Methyl-transferase JerF from the Late Stages of Jera ...
In: Molecules Bd. 21 (2016) Heft 11
doi:10.3390/molecules21111443 ...

Berkhan, Gesche; Merten, Christian; Holec, Claudia; Hahn, Frank
The Interplay between a Multifunctional Dehydratase Domain and a C-Methyltransferase Effects Ol ...
In: Angewandte Chemie International Edition Bd. 55 (2016) Heft 43. - S. 13589-13592
doi:10.1002/anie.201607827 ...

2015

Friedrich, Steffen; Hahn, Frank
Opportunities for enzyme catalysis in natural product chemistry
In: Tetrahedron Bd. 71 (2015) Heft 10. - S. 1473-1508
doi:10.1016/j.tet.2014.12.026 ...

2014

Berkhan, Gesche; Hahn, Frank
A Dehydratase Domain in Ambruticin Biosynthesis Displays Additional Activity as a Pyran-Forming ...
In: Angewandte Chemie International Edition Bd. 53 (2014) Heft 15. - S. 14240-14244
doi:10.1002/anie.201407979 ...

Hemmerling, Franziska; Hahn, Frank
Neue Wege in der Naturstoffforschung : Die erfolgreiche Verbindung von Synthesechemie und Biote ...
In: GIT : Labor-Fachzeitschrift Bd. 58 (2014) Heft 5. - S. 48

Hahn, Frank; Kandziora, Nadine; Friedrich, Steffen; Leadlay, Peter F.
Synthesis of complex intermediates for the study of a dehydratase from borrelidin biosynthesis
In: Beilstein Journal of Organic Chemistry Bd. 10 (2014) . - S. 634-640
doi:10.3762/bjoc.10.55 ...

Kandziora, Nadine; Andexer, Jennifer N.; Moss, Steven J.; Wilkinson, Barrie; Leadlay, Peter F.; Hahn, Frank
Uncovering the origin of Z-configured double bonds in polyketides : intermediate E-double bond ...
In: Chemical Science Bd. 5 (2014) Heft 9. - S. 3563-3567
doi:10.1039/C4SC00883A ...

2013

Fürniss, Daniel; Mack, Timo; Hahn, Frank; Vollrath, Sidonie B. L.; Koroniak, Katarzyna; Schepers, Ute; Bräse, Stefan
Peptoids and polyamines going sweet : Modular synthesis of glycosylated peptoids and polyamines ...
In: Beilstein Journal of Organic Chemistry Bd. 9 (2013) . - S. 56-63
doi:10.3762/bjoc.9.7 ...

Kanchanabanca, Chompoonik; Tao, Weixin; Hong, Hui; Liu, Yajing; Hahn, Frank; Samborskyy, Markiyan; Deng, Zixin; Sun, Yuhui; Leadlay, Peter F.
Unusual Acetylation–Elimination in the Formation of Tetronate Antibiotics
In: Angewandte Chemie International Edition Bd. 52 (2013) Heft 22. - S. 5785-5788
doi:10.1002/anie.201301680 ...

2012

Kirschning, Andreas; Hahn, Frank
Merging Chemical Synthesis and Biosynthesis : A New Chapter in the Total Synthesis of Natural P ...
In: Angewandte Chemie International Edition Bd. 51 (2012) Heft 17. - S. 4012-4022
doi:10.1002/anie.201107386 ...

2011

Vergnolle, Olivia; Hahn, Frank; Baerga-Ortiz, Abel; Leadlay, Peter F.; Andexer, Jennifer N.
Stereoselectivity of Isolated Dehydratase Domains of the Borrelidin Polyketide Synthase : Impli ...
In: ChemBioChem Bd. 12 (2011) Heft 7. - S. 1011-1014
doi:10.1002/cbic.201100011 ...

2010

Sun, Yuhui; Hahn, Frank; Demydchuk, Yuliya; Chettle, James; Tosin, Manuela; Osada, Hiroyuki; Leadlay, Peter F.
In vitro reconstruction of tetronate RK-682 biosynthesis
In: Nature Chemical Biology Bd. 6 (2010) . - S. 99-101
doi:10.1038/nchembio.285 ...

Schmitz, Katja; Hahn, Frank; Schepers, Ute
Modified GSMP Synthesis Greatly Improves the Disulfide Crosslink of T7 Run-Off siRNAs with Cell ...
In: Synlett (2010) Heft 19. - S. 2959-2963
doi:10.1055/s-0030-1259022 ...

Chavarot-Kerlidou, Murielle; Rivard, Michaël; Chamiot, Bénédicte; Hahn, Frank; Rose-Munch, Françoise; Rose, Eric; Py, Sandrine; Herson, Patrick
Synthesis and Structural Characterization of Planar Chiral Cr(CO)3-Complexed Aromatic Nitrones ...
In: European Journal of Organic Chemistry (2010) Heft 5. - S. 944-958
doi:10.1002/ejoc.200900836 ...

2009

Hahn, Frank; Schepers, Ute
Thieme Chemistry Journal Awardees - Where are They Now? : A Convenient Route for Introduction o ...
In: Synlett (2009) Heft 17. - S. 2755-2760
doi:10.1055/s-0029-1217987 ...

2008

Hahn, Frank; Müllen, Klaus; Schepers, Ute
2-Iminothiolane as a Useful Coupling Reagent for Polyamine Solid-Phase Synthesis
In: Synlett (2008) Heft 18. - S. 2785-2790
doi:10.1055/s-0028-1083566 ...

Hahn, Frank; Schmitz, Katja; Balaban, Theodor S.; Bräse, Stefan
Conjugation of Spermine Facilitates Cellular Uptake and Enhances Antitumor and Antibiotic Prope ...
In: ChemMedChem Bd. 3 (2008) Heft 8. - S. 1185-1188
doi:10.1002/cmdc.200800013 ...

Hahn, Frank; Schepers, Ute
Versatile Procedure for Asymmetric and Orthogonal Protection of Symmetric Polyamines and Its Ad ...
In: Journal of Combinatorial Chemistry Bd. 10 (2008) Heft 2. - S. 267-272
doi:10.1021/cc700119g ...

2007

Hahn, Frank; Schepers, Ute
Solid Phase Chemistry for the Directed Synthesis of Biologically Active Polyamine Analogs, Deri ...
Combinatorial chemistry on solid supports
Berlin : Springer, 2007. - S. 135-208 . - (Topics in Current Chemistry; 278)
https://link.springer.com/content/pdf/10.1007%2F12 ...