Prof. Dr. Clemens Steegborn

Person
Research priorities
Publications
Contact

Faculty of Biology, Chemistry & Earth Sciences
Chair of Biochemistry

Job History

02/2010 – present	University of Bayreuth, Dept. Biochemistry, Bayreuth, Germany Full Professor (W3) and Chair for Biochemistry Research topic: Molecular signaling mechanisms in aging and aging-related diseases
03/2005 – 01/2010	Ruhr-University Bochum, Dept. Physiological Chemistry, Jun.-Professor in Biochemistry Research topic: Structural and biochemical studies on the regulation of signaling enzymes in aging and disease

Education

12/2001 – 02/2005	Weill Medical College of Cornell University, New York, NY, USA Postdoctoral Research Associate in the laboratory of Professor Hao Wu Research Topic: Structural studies on intracellular signaling systems
10/1997 – 09/2001	Max-Planck-Institute of Biochemistry, Martinsried, Germany Ph.D. in Biochemistry, summa cum laude, March 2001 Thesis Advisor: Professor Robert Huber Thesis Topic: Biochemical and X-ray crystallographic studies on transcriptional activator MalT and the pyridoxal-5’-phosphate dependent enzymes cystathionine y-synthase and cystathionine y-lyase
1992 – 1997	University of Bayreuth, Department of Biochemistry, Bayreuth, Germany Diploma (M.S.) in Biochemistry, passed with distinction, August 1997 Thesis Advisor: Professor Franz-Xaver Schmid Thesis Topic: Structure of a folding intermediate of ribonuclease T1 studied by NMR spectroscopy

Awards and other responsibilities

2002 – 2005	Berger Fellow of the Damon Runyon Cancer Research Foundation
2001	Max-Planck postdoctoral fellowship
1998 – 2000	“Boehringer Ingelheim Fonds” predoctoral fellowship
1996 – 1997	Scholarship of the “Studienstiftung des Deutschen Volkes” foundation
1995	European Union TEMPUS scholarship
1991	“Fonds der chemischen Industrie” chemistry award
1998	“Begabtenfoerderung” (gifted pupils award) by the land Baden-Wuerttemberg
Functions:
2010 – present	Deputy Director, Institute for Biomacromolecules (BIOmac), Univ. Bayreuth
06/2012 – 01/2014	Speaker, Profile Area “Molecular Biosciences, University of Bayreuth
2012 – present	German Society for Biochemistry and Molecular Biology (GBM)

Faculty of Biology, Chemistry & Earth Sciences
Chair of Biochemistry

Molecular signalling mechanisms in aging and disease
- Sirtuin family of deacetylases
- Cyclic nucleotide signalling
- Redox enzymes and signalling

Protein function and regulation analysis through biochemical studies and x-ray crystallography
Structure-assisted drug development

Faculty of Biology, Chemistry & Earth Sciences
Chair of Biochemistry

Selected publications

2024

Sun, Shan; Fushimi, Makoto; Rossetti, Thomas; Kaur, Navpreet; Ferreira, Jacob; Miller, Michael; Quast, Jonathan; van den Heuvel, Joop; Steegborn, Clemens; Levin, Lonny R.; Buck, Jochen; Myers, Robert W.; Kargman, Stacia; Liverton, Nigel; Meinke, Peter T.; Huggins, David J.
Addition to "Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibit ...
in Journal of Chemical Information and Modeling volume 64 (2024) issue 3. - page 1106
doi:10.1021/acs.jcim.4c00068 ...

You, Weijie; Montoya, Alba L.; Dana, Srikanta; Franzini, Raphael M.; Steegborn, Clemens
Elucidating the Unconventional Binding Mode of a DNA‐Encoded Library Hit Provides a Blueprint f ...
in ChemMedChem (2024)
doi:10.1002/cmdc.202400273 ...

Wang, Jinping; Luo, Jinque; Rotili, Dante; Mai, Antonello; Steegborn, Clemens; Xu, Suowen; Jin, Zheng Gen
SIRT6 Protects Against Lipopolysaccharide-Induced Inflammation in Human Pulmonary Lung Microvas ...
in Inflammation volume 47 (2024) . - page 323-332
doi:10.1007/s10753-023-01911-5 ...

Pannek, Martin; Alhalabi, Zayan; Tomaselli, Daniela; Menna, Martina; Fiorentino, Francesco; Robaa, Dina; Weyand, Michael; Puhlmann, Maximilian; Tomassi, Stefano; Barreca, Federica; Tafani, Marco; Zaganjor, Elma; Haigis, Marcia C.; Sippl, Wolfgang; Rotili, Dante; Mai, Antonello; Steegborn, Clemens
Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity
in Journal of Medicinal Chemistry volume 67 (2024) issue 3. - page 1843-1860
doi:10.1021/acs.jmedchem.3c01496 ...

2023

Rossetti, Thomas; Ferreira, Jacob; Ghanem, Lubna; Buck, Hannes; Steegborn, Clemens; Myers, Robert W.; Meinke, Peter T.; Levin, Lonny R.; Buck, Jochen
Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitor ...
in Frontiers in Physiology volume 14 (2023)
doi:10.3389/fphys.2023.1163389 ...

Adolph, Ramona S.; Beck, Eileen; Schweimer, Kristian; Di Fonzo, Andrea; Weyand, Michael; Rösch, Paul; Wöhrl, Birgitta M.; Steegborn, Clemens
Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein
in Life volume 13 (2023) issue 4
doi:10.3390/life13040949 ...

Zwergel, Clemens; Aventaggiato, Michele; Garbo, Sabrina; Di Bello, Elisabetta; Fassari, Bruno; Noce, Beatrice; Castiello, Carola; Lambona, Chiara; Barreca, Federica; Rotili, Dante; Fioravanti, Rossella; Schmalz, Thomas; Weyand, Michael; Niedermeier, Amelie; Tripodi, Marco; Colotti, Gianni; Steegborn, Clemens; Battistelli, Cecilia; Tafani, Marco; Valente, Sergio; Mai, Antonello
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability an ...
in Journal of Medicinal Chemistry volume 66 (2023) issue 14. - page 9622-9641
doi:10.1021/acs.jmedchem.3c00337 ...

Balbach, Melanie; Rossetti, Thomas; Ferreira, Jacob; Ghanem, Lubna; Ritagliati, Carla; Myers, Robert W.; Huggins, David J.; Steegborn, Clemens; Miranda, Ileana C.; Meinke, Peter T.; Buck, Jochen; Levin, Lonny R.
On-demand male contraception via acute inhibition of soluble adenylyl cyclase
in Nature Communications volume 14 (2023) issue 1
doi:10.1038/s41467-023-36119-6 ...

Sun, Shan; Fushimi, Makoto; Rossetti, Thomas; Kaur, Navpreet; Ferreira, Jacob; Miller, Michael; Quast, Jonathan; van den Heuvel, Joop; Steegborn, Clemens; Levin, Lonny R.; Buck, Jochen; Myers, Robert W.; Kargman, Stacia; Liverton, Nigel; Meinke, Peter T.; Huggins, David J.
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Fr ...
in Journal of Chemical Information and Modeling volume 63 (2023) issue 9. - page 2828-2841
doi:10.1021/acs.jcim.2c01577 ...

2022

Rossetti, Thomas; Ferreira, Jacob; Ghanem, Lubna; Buck, Hannes; Steegborn, Clemens; Myers, Robert W.; Meinke, Peter T.; Levin, Lonny R.; Buck, Jochen
Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize ...
in Frontiers in Physiology volume 13 (2022)
doi:10.3389/fphys.2022.1013845 ...

Miller, Michael; Rossetti, Thomas; Ferreira, Jacob; Ghanem, Lubna; Balbach, Melanie; Kaur, Navpreet; Levin, Lonny R.; Buck, Jochen; Kehr, Maria; Coquille, Sandrine; van den Heuvel, Joop; Steegborn, Clemens; Fushimi, Makoto; Finkin-Groner, Efrat; Myers, Robert W.; Kargman, Stacia; Liverton, Nigel J.; Huggins, David J.; Meinke, Peter T.
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase ...
in Journal of Medicinal Chemistry volume 65 (2022) issue 22. - page 15208-15226
doi:10.1021/acs.jmedchem.2c01133 ...

Rodriguez-Ruiz, Alfonso; Braun, Doreen; Pflug, Simon; Brol, Alexander; Sylvester, Marc; Steegborn, Clemens; Schweizer, Ulrich
Insights into the Mechanism of Human Deiodinase 1
in International Journal of Molecular Sciences volume 23 (2022) issue 10
doi:10.3390/ijms23105361 ...

Suenkel, Benjamin; Valente, Sergio; Zwergel, Clemens; Weiss, Sandra; Di Bello, Elisabetta; Fioravanti, Rossella; Aventaggiato, Michele; Amorim, João A.; Garg, Neha; Kumar, Surinder; Lombard, David B.; Hu, Tuo; Singh, Pankaj K.; Tafani, Marco; Palmeira, Carlos M.; Sinclair, David; Mai, Antonello; Steegborn, Clemens
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5
in Journal of Medicinal Chemistry volume 65 (2022) issue 20. - page 14015-14031
doi:10.1021/acs.jmedchem.2c01215 ...

Weiss, Sandra; Adolph, Ramona S.; Schweimer, Kristian; DiFonzo, Andrea; Meleshin, Marat; Schutkowski, Mike; Steegborn, Clemens
Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein
in International Journal of Molecular Sciences volume 23 (2022) issue 21
doi:10.3390/ijms232112764 ...

2021

You, Weijie; Steegborn, Clemens
Binding site for activator MDL-801 on SIRT6
in Nature Chemical Biology volume 17 (2021) . - page 519-521
doi:10.1038/s41589-021-00749-y ...

Ip, James E.; Xu, Linna; Dai, Jie; Steegborn, Clemens; Jaffré, Fabrice; Evans, Todd; Cheung, Jim W.; Basson, Craig T.; Panaghie, Gianina; Krogh-Madsen, Trine; Abbott, Geoffrey W.; Lerman, Bruce B.
Constitutively Activating GNAS Somatic Mutation in Right Ventricular Outflow Tract Tachycardia
in Circulation: Arrhythmia and Electrophysiology volume 14 (2021) issue 10
doi:10.1161/CIRCEP.121.010082 ...

Fushimi, Makoto; Buck, Hannes; Balbach, Melanie; Gorovyy, Anna; Ferreira, Jacob; Rossetti, Thomas; Kaur, Navpreet; Levin, Lonny R.; Buck, Jochen; Quast, Jonathan; van den Heuvel, Joop; Steegborn, Clemens; Finkin-Groner, Efrat; Kargman, Stacia; Michino, Mayako; Foley, Michael A.; Miller, Michael; Liverton, Nigel J.; Huggins, David J.; Meinke, Peter T.
Discovery of TDI-10229 : A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase ...
in ACS Medicinal Chemistry Letters volume 12 (2021) issue 8. - page 1283-1287
doi:10.1021/acsmedchemlett.1c00273 ...

Hu, Tuo; Shukla, Surendra K.; Vernucci, Enza; He, Chunbo; Wang, Dezhen; King, Ryan J.; Jha, Kanupriya; Siddhanta, Kasturi; Mullen, Nicholas J.; Attri, Kuldeep S.; Murthy, Divya; Chaika, Nina V.; Thakur, Ravi; Mulder, Scott E.; Pacheco, Camila G.; Fu, Xiao; High, Robin R.; Yu, Fang; Lazenby, Audrey; Steegborn, Clemens; Lan, Ping; Mehla, Kamiya; Rotili, Dante; Chaudhary, Sarika; Valente, Sergio; Tafani, Marco; Mai, Antonello; Auwerx, Johan; Verdin, Eric; Tuveson, David; Singh, Pankaj K.
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression
in Gastroenterology volume 161 (2021) issue 5. - page 1584-1600
doi:10.1053/j.gastro.2021.06.045 ...

Unverzagt, Carlo; Reif, Andreas; Lam, Kevin; Weidler, Sascha; Lott, Marie; Boos, Irene; Lokau, Juliane; Bretscher, Christian; Mönnich, Manuel; Perkams, Lukas; Schmälzlein, Marina; Graf, Christopher G. F.; Fischer, Jan-Patrick; Lechner, Carolin; Hallstein, Kerstin; Becker, Stefan; Weyand, Michael; Steegborn, Clemens; Schultheiss, Gerhard; Rose-John, Stefan; Garbers, Christoph
Natural Glycoforms of Human Interleukin 6 show atypical plasma clearance
in Angewandte Chemie International Edition volume 60 (2021) issue 24. - page 13380-13387
doi:10.1002/anie.202101496 ...

2020

Steegborn, Clemens; Schweizer, Ulrich
Structure and Mechanism of Iodothyronine Deiodinases : What We Know, What We Don't Know, and Wh ...
in Experimental and clinical endocrinology & diabetes volume 128 (2020) issue 6/7. - page 375-378
doi:10.1055/a-1022-9916 ...

Kleinboelting, Silke; Miehling, Jonas; Steegborn, Clemens
Crystal structure and enzymatic characterization of the putative adenylyl cyclase HpAC1 from Hi ...
in Journal of Structural Biology volume 212 (2020) issue 3
doi:10.1016/j.jsb.2020.107649 ...

Linder, Jürgen; Hupfeld, Enrico; Weyand, Michael; Steegborn, Clemens; Moniot, Sébastien
Crystal structure of a class III adenylyl cyclase-like ATP-binding protein from Pseudomonas aer ...
in Journal of Structural Biology volume 211 (2020) issue 2
doi:10.1016/j.jsb.2020.107534 ...

Tomassi, Stefano; Pfahler, Julian; Mautone, Nicola; Rovere, Anarita; Esposito, Chiara; Passeri, Daniela; Pellicciari, Roberto; Novellino, Ettore; Pannek, Martin; Steegborn, Clemens; Paiardini, Alessandro; Mai, Antonello; Rotili, Dante
From PARP1 to TNKS2 Inhibition : A Structure-Based Approach
in ACS Medicinal Chemistry Letters volume 11 (2020) issue 5. - page 862-868
doi:10.1021/acsmedchemlett.9b00654 ...

Balbach, Melanie; Fushimi, Makoto; Huggins, David J.; Steegborn, Clemens; Meinke, Peter T.; Levin, Lonny R.; Buck, Jochen
Optimization of lead compounds into on-demand, nonhormonal contraceptives : leveraging a public ...
in Biology of Reproduction volume 103 (2020) issue 2. - page 176-182
doi:10.1093/biolre/ioaa052 ...

Tomaselli, Daniela; Steegborn, Clemens; Mai, Antonello; Rotili, Dante
Sirt4 : A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer
in Frontiers in Oncology volume 10 (2020)
doi:10.3389/fonc.2020.00474 ...

Teodoro, João S.; Amorim, João Alves; Machado, Ivo F.; Castela, Ana C.; Steegborn, Clemens; Sinclair, David A.; Rolo, Anabel P.; Palmeira, Carlos M.
The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Throug ...
in International Journal of Molecular Sciences volume 21 (2020) issue 14
doi:10.3390/ijms21144896 ...

You, Weijie; Steegborn, Clemens
Structural Basis for Activation of Human Sirtuin 6 by Fluvastatin
in ACS Medicinal Chemistry Letters volume 11 (2020) issue 11. - page 2285-2289
doi:10.1021/acsmedchemlett.0c00407 ...

2019

Weber, Anna M.; Kaiser, Jennifer; Ziegler, Thea; Pilsl, Sebastian; Renzl, Christian; Sixt, Lisa; Pietruschka, Georg; Moniot, Sébastien; Kakoti, Ankana; Juraschitz, Marc; Schrottke, Stefanie; Lledo Bryant, Laura; Steegborn, Clemens; Bittl, Robert; Mayer, Günter; Möglich, Andreas
A blue light receptor that mediates RNA binding and translational regulation
in Nature Chemical Biology volume 15 (2019) . - page 1085-1092
doi:10.1038/s41589-019-0346-y ...

Palmeira, Carlos Marques; Teodoro, João S.; Amorim, João Alves; Steegborn, Clemens; Sinclair, David A.; Rolo, Anabela Pinto
Mitohormesis and metabolic health : the interplay between ROS, cAMP and sirtuins
in Free Radical Biology and Medicine volume 141 (2019) . - page 483-491
doi:10.1016/j.freeradbiomed.2019.07.017 ...

You, Weijie; Zheng, Wei; Weiß, Sandra; Chua, Katrin F.; Steegborn, Clemens
Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivative ...
in Scientific Reports volume 9 (2019)
doi:10.15495/EPub_UBT_00004703 ...

2018

Wiggins, Shakarr V.; Steegborn, Clemens; Levin, Lonny R.; Buck, Jochen
Pharmacological modulation of the CO₂/HCO₃⁻/pH-, calcium-, and ATP-sensing soluble adenylyl cyc ...
in Pharmacology & Therapeutics volume 190 (2018) . - page 173-186
doi:10.1016/j.pharmthera.2018.05.008 ...

Dai, Han; Sinclair, David A.; Ellis, James L.; Steegborn, Clemens
Sirtuin activators and inhibitors : Promises, achievements, and challenges
in Pharmacology & Therapeutics volume 188 (2018) . - page 140-154
doi:10.1016/j.pharmthera.2018.03.004 ...

Pinto, Andrea; El Ali, Zeina; Moniot, Sébastien; Tamborini, Lucia; Steegborn, Clemens; Foresti, Roberta; de Micheli, Carlo
Effects of 3-Bromo-4,5-dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase-1 Exp ...
in ChemistryOpen volume 7 (2018) issue 11. - page 858-864
doi:10.1002/open.201800185 ...

Lachettini, Sara; Trisciuoglio, Daniela; Rotili, Dante; Lucidi, Alessia; Salvati, Erica; Zizza, Pasquale; di Leo, Luca; del Bufalo, Donatella; Ciriolo, Maria Rosa; Leonetti, Carlo; Steegborn, Clemens; Mai, Antonello; Rizzo, Angela; Biroccio, Annamaria
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells
in Cell Death & Disease volume 9 (2018)
doi:10.1038/s41419-018-1065-0 ...

Kalbas, Diana; Liebscher, Sandra; Nowak, Theresa; Meleshin, Marat; Pannek, Martin; Popp, Corinna; Alhalabi, Zayan; Bordusa, Frank; Sippl, Wolfgang; Steegborn, Clemens; Schutkowski, Mike
Potent and Selective Inhibitors of Human Sirtuin 5
in Journal of Medicinal Chemistry volume 61 (2018) issue 6. - page 2460-2471
doi:10.1021/acs.jmedchem.7b01648 ...

You, Weijie; Steegborn, Clemens
Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A : Implications for P ...
in Journal of Medicinal Chemistry volume 61 (2018) issue 23. - page 10922-10928
doi:10.1021/acs.jmedchem.8b01455 ...

2017

Pannek, Martin; Simic, Zeljko; Fuszard, Matthew; Meleshin, Marat; Rotili, Dante; Mai, Antonello; Schutkowski, Mike; Steegborn, Clemens
Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recogn ...
in Nature Communications volume 8 (2017)
doi:10.1038/s41467-017-01701-2 ...

Li, Jun; Bonkowski, Michael S.; Moniot, Sébastien; Zhang, Dapeng; Hubbard, Basil P.; Ling, Alvin J. Y.; Rajman, Luis A.; Qin, Bo; Lou, Zhenkun; Gorbunova, Vera; Aravind, L.; Steegborn, Clemens; Sinclair, David A.
A conserved NAD+ binding pocket that regulates protein-protein interactions during aging
in Science volume 355 (2017) issue 6331. - page 1312-1317
doi:10.1126/science.aad8242 ...

de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; Lázaro, Diana F.; Moniot, Sébastien; Guerreiro, Patrícia; Fonseca-Ornelas, Luis; Marijanovic, Zrinka; Antas, Pedro; Gerhardt, Ellen; Enguita, Francisco Javier; Fauvet, Bruno; Penque, Deborah; Pais, Teresa Faria; Tong, Qiang; Becker, Stefan; Kügler, Sebastian; Lashuel, Hilal Ahmed; Steegborn, Clemens; Zweckstetter, Markus; Outeiro, Tiago F.
Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in mod ...
in PLoS Biology volume 15 (2017) issue 4
doi:10.1371/journal.pbio.1002601 ...

Moniot, Sébastien; Forgione, Mariantonietta; Lucidi, Alessia; Hailu, Gebremedhin S.; Nebbioso, Angela; Carafa, Vincenzo; Baratta, Francesca; Altucci, Lucia; Giacché, Nicola; Passeri, Daniela; Pellicciari, Roberto; Mai, Antonello; Steegborn, Clemens; Rotili, Dante
Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Si ...
in Journal of Medicinal Chemistry volume 60 (2017) issue 6. - page 2344-2360
doi:10.1021/acs.jmedchem.6b01609 ...

Quinti, Luisa; Dayalan Naidu, Sharadha; Träger, Ulrike; Chen, Xiqun; Kegel-Gleason, Kimberly; Llères, David; Connolly, Colúm; Chopra, Vanita; Low, Cho; Moniot, Sébastien; Sapp, Ellen; Tousley, Adelaide R.; Vodicka, Petr; van Kanegan, Michael J.; Kaltenbach, Linda S.; Crawford, Lisa A.; Fuszard, Matthew; Higgins, Maureen; Miller, James R. C.; Farmer, Ruth E.; Potluri, Vijay; Samajdar, Susanta; Meisel, Lisa; Zhang, Ningzhe; Snyder, Andrew; Stein, Ross; Hersch, Steven M.; Ellerby, Lisa M.; Weerapana, Eranthie; Schwarzschild, Michael A.; Steegborn, Clemens; Leavitt, Blair R.; Degterev, Alexei; Tabrizi, Sarah J.; Lo, Donald C.; DiFiglia, Marian; Thompson, Leslie M.; Dinkova-Kostova, Albena T.; Kazantsev, Aleksey G.
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from ...
in Proceedings of the National Academy of Sciences of the United States of America volume 114 (2017) issue 23
doi:10.1073/pnas.1614943114 ...

de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; Lázaro, Diana F.; Moniot, Sébastien; Guerreiro, Patrícia; Fonseca, Luis; Marijanovic, Zrinka; Antas, Pedro; Gerhardt, Ellen; Enguita, Francisco Javier; Fauvet, Bruno; Penque, Deborah; Pais, Teresa Faria; Tong, Qiang; Becker, Stefan; Kügler, Sebastian; Lashuel, Hilal Ahmed; Steegborn, Clemens; Zweckstetter, Markus; Outeiro, Tiago F.
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parki ...
in PLoS Biology volume 15 (2017) issue 3
doi:10.1371/journal.pbio.2000374 ...

Rajabi, Nima; Auth, Marina; Troelsen, Kathrin R.; Pannek, Martin; Bhatt, Dhaval; Fontenas, Martin; Hirshey, Matthew D.; Steegborn, Clemens; Madsen, Andreas S.; Olsen, Christian Adam
Mechanism-based Inhibitors of the Human Sirtuin 5 Deacylase : Structure-Activity Relationship, ...
in Angewandte Chemie International Edition volume 56 (2017) issue 47. - page 14836-14841
doi:10.1002/anie.201709050 ...

Schweizer, Ulrich; Towell, Holly; Vit, Allegra; Rodriguez-Ruiz, Alfonso; Steegborn, Clemens
Structural aspects of thyroid hormone binding to proteins and competitive interactions with nat ...
in Molecular and Cellular Endocrinology volume 458 (2017) . - page 57-67
doi:10.1016/j.mce.2017.01.026 ...

You, Weijie; Rotili, Dante; Li, Tie-Mei; Kambach, Christian; Meleshin, Marat; Schutkowski, Mike; Chua, Katrin F.; Mai, Antonello; Steegborn, Clemens
Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules
in Angewandte Chemie International Edition volume 56 (2017) issue 4. - page 1007-1011
doi:10.1002/anie.201610082 ...

Graf, Christopher G. F.; Schulz, Christian; Schmälzlein, Marina; Heinlein, Christian; Mönnich, Manuel; Perkams, Lukas; Püttner, Markus; Boos, Irene; Hessefort, Markus; Lombana Sanchez, Jose Nelson; Weyand, Michael; Steegborn, Clemens; Breiden, Bernadette; Ross, Kerstin; Schwarzmann, Günter; Sandhoff, Konrad; Unverzagt, Carlo
Synthetic Glycoforms Reveal Carbohydrate-Dependent Bioactivity of Human Saposin D
in Angewandte Chemie International Edition volume 56 (2017) issue 19. - page 5252-5257
doi:10.1002/anie.201701362 ...

Sundriyal, Sandeep; Moniot, Sébastien; Mahmud, Zimam; Yao, Shang; di Fruscia, Paolo; Reynolds, Christopher R.; Dexter, David T.; Sternberg, Michael J. E.; Lam, Eric W.-F.; Steegborn, Clemens; Fuchter, Matthew J.
Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Sele ...
in Journal of Medicinal Chemistry volume 60 (2017) issue 5. - page 1928-1945
doi:10.1021/acs.jmedchem.6b01690 ...

2016

Ramos-Espiritu, Lavoisier; Kleinbölting, Silke; Navarrete, Felipe A.; Alvau, Antonio; Visconti, Pablo E.; Valsecchi, Federica; Starkov, Anatoly; Manfredi, Giovanni; Buck, Hannes; Adura, Carolina; Zippin, Jonathan H.; van den Heuvel, Joop; Glickman, J. Fraser; Steegborn, Clemens; Levin, Lonny R.; Buck, Jochen
Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase
in Nature Chemical Biology volume 12 (2016) issue 10. - page 838-844
doi:10.1038/nchembio.2151 ...

Valente, Sergio; Mellini, Paolo; Spallotta, Francesco; Carafa, Vincenzo; Nebbioso, Angela; Polletta, Lucia; Carnevale, Ilaria; Saladini, Serena; Trisciuoglio, Daniela; Gabellini, Chiara; Tardugno, Maria; Zwergel, Clemens; Cencioni, Chiara; Atlante, Sandra; Moniot, Sébastien; Steegborn, Clemens; Budriesi, Roberta; Tafani, Marco; del Bufalo, Donatella; Altucci, Lucia; Gaetano, Carlo; Mai, Antonello
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial ...
in Journal of Medicinal Chemistry volume 59 (2016) issue 4. - page 1471-1491
doi:10.1021/acs.jmedchem.5b01117 ...

Kleinbölting, Silke; Ramos-Espiritu, Lavoisier; Buck, Hannes; Colis, Laureen; van den Heuvel, Joop; Glickman, J. Fraser; Levin, Lonny R.; Buck, Jochen; Steegborn, Clemens
Bithionol potently inhibits human soluble adenylyl cyclase through binding to the allosteric ac ...
in The Journal of Biological Chemistry volume 291 (2016) issue 18. - page 9776-9784
doi:10.1074/jbc.M115.708255 ...

Schuster, Sabine; Roessler, Claudia; Meleshin, Marat; Zimmermann, Philipp; Simic, Zeljko; Kambach, Christian; Schiene-Fischer, Cordelia; Steegborn, Clemens; Hottiger, Michael O.; Schutkowski, Mike
A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions
in Scientific Reports volume 6 (2016)
doi:10.1038/srep22643 ...

Klionsky, Daniel J; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Acevedo Arozena, Abraham; Adachi, Hiroaki; Adams, Christopher M; Adams, Peter D; Adeli, Khosrow; Adhihetty, Peter J; Adler, Sharon G; Agam, Galila; Agarwal, Rajesh; Aghi, Manish K; Agnello, Maria; Agostinis, Patrizia; Aguilar, Patricia V; Aguirre-Ghiso, Julio; Airoldi, Edoardo M; Ait-Si-Ali, Slimane; Akematsu, Takahiko; Akporiaye, Emmanuel T; Al-Rubeai, Mohamed; Albaiceta, Guillermo M; Albanese, Chris; Albani, Diego; Albert, Matthew L; Aldudo, Jesus; Algül, Hana; Alirezaei, Mehrdad; Alloza, Iraide; Almasan, Alexandru; Almonte-Beceril, Maylin; Alnemri, Emad S; Alonso, Covadonga; Altan-Bonnet, Nihal; Altieri, Dario C; Alvarez, Silvia; Alvarez-Erviti, Lydia; Alves, Sandro; Amadoro, Giuseppina; Amano, Atsuo; Amantini, Consuelo; Ambrosio, Santiago; Amelio, Ivano; Amer, Amal O; Amessou, Mohamed; Amon, Angelika; An, Zhenyi; Anania, Frank A; Andersen, Stig U; Andley, Usha P; Andreadi, Catherine K; Andrieu-Abadie, Nathalie; 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Fisher, Paul B; Flajolet, Marc; Flamigni, Flavio; Florey, Oliver; Florio, Salvatore; Floto, R Andres; Folini, Marco; Follo, Carlo; Fon, Edward A; Fornai, Francesco; Fortunato, Franco; Fraldi, Alessandro; Franco, Rodrigo; Francois, Arnaud; François, Aurélie; Frankel, Lisa B; Fraser, Iain Dc; Frey, Norbert; Freyssenet, Damien G; Frezza, Christian; Friedman, Scott L; Frigo, Daniel E; Fu, Dongxu; Fuentes, José M; Fueyo, Juan; Fujitani, Yoshio; Fujiwara, Yuuki; Fujiya, Mikihiro; Fukuda, Mitsunori; Fulda, Simone; Fusco, Carmela; Gabryel, Bozena; Gaestel, Matthias; Gailly, Philippe; Gajewska, Malgorzata; Galadari, Sehamuddin; Galili, Gad; Galindo, Inmaculada; Galindo, Maria F; Galliciotti, Giovanna; Galluzzi, Lorenzo; Galluzzi, Luca; Galy, Vincent; Gammoh, Noor; Gandy, Sam; Ganesan, Anand K; Ganesan, Swamynathan; Ganley, Ian G; Gannagé, Monique; Gao, Fen-Biao; Gao, Feng; Gao, Jian-Xin; García Nannig, Lorena; García Véscovi, Eleonora; Garcia-Macía, Marina; Garcia-Ruiz, Carmen; Garg, Abhishek D; Garg, Pramod Kumar; Gargini, Ricardo; Gassen, Nils Christian; Gatica, Damián; Gatti, Evelina; Gavard, Julie; Gavathiotis, Evripidis; Ge, Liang; Ge, Pengfei; Ge, Shengfang; Gean, Po-Wu; Gelmetti, Vania; Genazzani, Armando A; Geng, Jiefei; Genschik, Pascal; Gerner, Lisa; Gestwicki, Jason E; Gewirtz, David A; Ghavami, Saeid; Ghigo, Eric; Ghosh, Debabrata; Giammarioli, Anna Maria; Giampieri, Francesca; Giampietri, Claudia; Giatromanolaki, Alexandra; Gibbings, Derrick J; Gibellini, Lara; Gibson, Spencer B; Ginet, Vanessa; Giordano, Antonio; Giorgini, Flaviano; Giovannetti, Elisa; Girardin, Stephen E; Gispert, Suzana; Giuliano, Sandy; Gladson, Candece L; Glavic, Alvaro; Gleave, Martin; Godefroy, Nelly; Gogal, Robert M; Gokulan, Kuppan; Goldman, Gustavo H; Goletti, Delia; Goligorsky, Michael S; Gomes, Aldrin V; Gomes, Ligia C; Gomez, Hernando; Gomez-Manzano, Candelaria; Gómez-Sánchez, Rubén; Gonçalves, Dawit Ap; Goncu, Ebru; Gong, Qingqiu; Gongora, Céline; Gonzalez, Carlos B; Gonzalez-Alegre, Pedro; 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Kim, Jin Hyoung; Kim, Kwang Woon; Kim, Michael D; Kim, Moon-Moo; Kim, Peter K; Kim, Seong Who; Kim, Soo-Youl; Kim, Yong-Sun; Kim, Yonghyun; Kimchi, Adi; Kimmelman, Alec C; Kimura, Tomonori; King, Jason S; Kirkegaard, Karla; Kirkin, Vladimir; Kirshenbaum, Lorrie A; Kishi, Shuji; Kitajima, Yasuo; Kitamoto, Katsuhiko; Kitaoka, Yasushi; Kitazato, Kaio; Kley, Rudolf A; Klimecki, Walter T; Klinkenberg, Michael; Klucken, Jochen; Knævelsrud, Helene; Knecht, Erwin; Knuppertz, Laura; Ko, Jiunn-Liang; Kobayashi, Satoru; Koch, Jan C; Koechlin-Ramonatxo, Christelle; Koenig, Ulrich; Koh, Young Ho; Köhler, Katja; Kohlwein, Sepp D; Koike, Masato; Komatsu, Masaaki; Kominami, Eiki; Kong, Dexin; Kong, Hee Jeong; Konstantakou, Eumorphia G; Kopp, Benjamin T; Korcsmaros, Tamas; Korhonen, Laura; Korolchuk, Viktor I; Koshkina, Nadya V; Kou, Yanjun; Koukourakis, Michael I; Koumenis, Constantinos; Kovács, Attila L; Kovács, Tibor; Kovacs, Werner J; Koya, Daisuke; Kraft, Claudine; Krainc, Dimitri; Kramer, Helmut; Kravic-Stevovic, Tamara; Krek, Wilhelm; Kretz-Remy, Carole; Krick, Roswitha; Krishnamurthy, Malathi; Kriston-Vizi, Janos; Kroemer, Guido; Kruer, Michael C; Kruger, Rejko; Ktistakis, Nicholas T; Kuchitsu, Kazuyuki; Kuhn, Christian; Kumar, Addanki Pratap; Kumar, Anuj; Kumar, Ashok; Kumar, Deepak; Kumar, Dhiraj; Kumar, Rakesh; Kumar, Sharad; Kundu, Mondira; Kung, Hsing-Jien; Kuno, Atsushi; Kuo, Sheng-Han; Kuret, Jeff; Kurz, Tino; Kwok, Terry; Kwon, Taeg Kyu; Kwon, Yong Tae; Kyrmizi, Irene; La Spada, Albert R; Lafont, Frank; Lahm, Tim; Lakkaraju, Aparna; Lam, Truong; Lamark, Trond; Lancel, Steve; Landowski, Terry H; Lane, Darius Jr; Lane, Jon D; Lanzi, Cinzia; Lapaquette, Pierre; Lapierre, Louis R; Laporte, Jocelyn; Laukkarinen, Johanna; Laurie, Gordon W; Lavandero, Sergio; Lavie, Lena; LaVoie, Matthew J; Law, Betty Yuen Kwan; Law, Helen Ka-Wai; Law, Kelsey B; Layfield, Robert; Lazo, Pedro A; Le Cam, Laurent; Le Roch, Karine G; Le Stunff, Hervé; Leardkamolkarn, Vijittra; Lecuit, Marc; Lee, Byung-Hoon; Lee, Che-Hsin; Lee, Erinna F; Lee, Gyun Min; Lee, He-Jin; Lee, Hsinyu; Lee, Jae Keun; Lee, Jongdae; Lee, Ju-Hyun; Lee, Jun Hee; Lee, Michael; Lee, Myung-Shik; Lee, Patty J; Lee, Sam W; Lee, Seung-Jae; Lee, Shiow-Ju; Lee, Stella Y; Lee, Sug Hyung; Lee, Sung Sik; Lee, Sung-Joon; Lee, Sunhee; Lee, Ying-Ray; Lee, Yong J; Lee, Young H; Leeuwenburgh, Christiaan; Lefort, Sylvain; Legouis, Renaud; Lei, Jinzhi; Lei, Qun-Ying; Leib, David A; Leibowitz, Gil; Lekli, Istvan; Lemaire, Stéphane D; Lemasters, John J; Lemberg, Marius K; Lemoine, Antoinette; Leng, Shuilong; Lenz, Guido; Lenzi, Paola; Lerman, Lilach O; Lettieri Barbato, Daniele; Leu, Julia I-Ju; Leung, Hing Y; Levine, Beth; Lewis, Patrick A; Lezoualc'h, Frank; Li, Chi; Li, Faqiang; Li, Feng-Jun; Li, Jun; Li, Ke; Li, Lian; Li, Min; Li, Min; Li, Qiang; Li, Rui; Li, Sheng; Li, Wei; Li, Wei; Li, Xiaotao; Li, Yumin; Lian, Jiqin; Liang, Chengyu; Liang, Qiangrong; Liao, Yulin; Liberal, Joana; Liberski, Pawel P; Lie, Pearl; Lieberman, Andrew P; Lim, Hyunjung Jade; Lim, Kah-Leong; Lim, Kyu; Lima, Raquel T; Lin, Chang-Shen; Lin, Chiou-Feng; Lin, Fang; Lin, Fangming; Lin, Fu-Cheng; Lin, Kui; Lin, Kwang-Huei; Lin, Pei-Hui; Lin, Tianwei; Lin, Wan-Wan; Lin, Yee-Shin; Lin, Yong; Linden, Rafael; Lindholm, Dan; Lindqvist, Lisa M; Lingor, Paul; Linkermann, Andreas; Liotta, Lance A; Lipinski, Marta M; Lira, Vitor A; Lisanti, Michael P; Liton, Paloma B; Liu, Bo; Liu, Chong; Liu, Chun-Feng; Liu, Fei; Liu, Hung-Jen; Liu, Jianxun; Liu, Jing-Jing; Liu, Jing-Lan; Liu, Ke; Liu, Leyuan; Liu, Liang; Liu, Quentin; Liu, Rong-Yu; Liu, Shiming; Liu, Shuwen; Liu, Wei; Liu, Xian-De; Liu, Xiangguo; Liu, Xiao-Hong; Liu, Xinfeng; Liu, Xu; Liu, Xueqin; Liu, Yang; Liu, Yule; Liu, Zexian; Liu, Zhe; Liuzzi, Juan P; Lizard, Gérard; Ljujic, Mila; Lodhi, Irfan J; Logue, Susan E; Lokeshwar, Bal L; Long, Yun Chau; Lonial, Sagar; Loos, Benjamin; López-Otín, Carlos; López-Vicario, Cristina; Lorente, Mar; Lorenzi, Philip L; Lõrincz, Péter; Los, Marek; Lotze, Michael T; Lovat, Penny E; Lu, Binfeng; Lu, Bo; Lu, Jiahong; Lu, Qing; Lu, She-Min; Lu, Shuyan; Lu, Yingying; Luciano, Frédéric; Luckhart, Shirley; Lucocq, John Milton; Ludovico, Paula; Lugea, Aurelia; Lukacs, Nicholas W; Lum, Julian J; Lund, Anders H; Luo, Honglin; Luo, Jia; Luo, Shouqing; Luparello, Claudio; Lyons, Timothy; Ma, Jianjie; Ma, Yi; Ma, Yong; Ma, Zhenyi; Machado, Juliano; Machado-Santelli, Glaucia M; Macian, Fernando; MacIntosh, Gustavo C; MacKeigan, Jeffrey P; Macleod, Kay F; MacMicking, John D; MacMillan-Crow, Lee Ann; Madeo, Frank; Madesh, Muniswamy; Madrigal-Matute, Julio; Maeda, Akiko; Maeda, Tatsuya; Maegawa, Gustavo; Maellaro, Emilia; Maes, Hannelore; Magariños, Marta; Maiese, Kenneth; Maiti, Tapas K; Maiuri, Luigi; Maiuri, Maria Chiara; Maki, Carl G; Malli, Roland; Malorni, Walter; Maloyan, Alina; Mami-Chouaib, Fathia; Man, Na; Mancias, Joseph D; Mandelkow, Eva-Maria; Mandell, Michael A; Manfredi, Angelo A; Manié, Serge N; Manzoni, Claudia; Mao, Kai; Mao, Zixu; Mao, Zong-Wan; Marambaud, Philippe; Marconi, Anna Maria; Marelja, Zvonimir; Marfe, Gabriella; Margeta, Marta; Margittai, Eva; Mari, Muriel; Mariani, Francesca V; Marin, Concepcio; Marinelli, Sara; Mariño, Guillermo; Markovic, Ivanka; Marquez, Rebecca; Martelli, Alberto M; Martens, Sascha; Martin, Katie R; Martin, Seamus J; Martin, Shaun; Martin-Acebes, Miguel A; Martín-Sanz, Paloma; Martinand-Mari, Camille; Martinet, Wim; Martinez, Jennifer; Martinez-Lopez, Nuria; Martinez-Outschoorn, Ubaldo; Martínez-Velázquez, Moisés; Martinez-Vicente, Marta; Martins, Waleska Kerllen; Mashima, Hirosato; Mastrianni, James A; Matarese, Giuseppe; Matarrese, Paola; Mateo, Roberto; Matoba, Satoaki; Matsumoto, Naomichi; Matsushita, Takehiko; Matsuura, Akira; Matsuzawa, Takeshi; Mattson, Mark P; Matus, Soledad; Maugeri, Norma; Mauvezin, Caroline; Mayer, Andreas; Maysinger, Dusica; Mazzolini, Guillermo D; McBrayer, Mary Kate; McCall, Kimberly; McCormick, Craig; McInerney, Gerald M; McIver, Skye C; McKenna, Sharon; McMahon, John J; McNeish, Iain A; Mechta-Grigoriou, Fatima; Medema, Jan Paul; Medina, Diego L; Megyeri, Klara; Mehrpour, Maryam; Mehta, Jawahar L; Mei, Yide; Meier, Ute-Christiane; Meijer, Alfred J; Meléndez, Alicia; Melino, Gerry; Melino, Sonia; de Melo, Edesio Jose Tenorio; Mena, Maria A; Meneghini, Marc D; Menendez, Javier A; Menezes, Regina; Meng, Liesu; Meng, Ling-Hua; Meng, Songshu; Menghini, Rossella; Menko, A Sue; Menna-Barreto, Rubem Fs; Menon, Manoj B; Meraz-Ríos, Marco A; Merla, Giuseppe; Merlini, Luciano; Merlot, Angelica M; Meryk, Andreas; Meschini, Stefania; Meyer, Joel N; Mi, Man-Tian; Miao, Chao-Yu; Micale, Lucia; Michaeli, Simon; Michiels, Carine; Migliaccio, Anna Rita; Mihailidou, Anastasia Susie; Mijaljica, Dalibor; Mikoshiba, Katsuhiko; Milan, Enrico; Miller-Fleming, Leonor; Mills, Gordon B; Mills, Ian G; Minakaki, Georgia; Minassian, Berge A; Ming, Xiu-Fen; Minibayeva, Farida; Minina, Elena A; Mintern, Justine D; Minucci, Saverio; Miranda-Vizuete, Antonio; Mitchell, Claire H; Miyamoto, Shigeki; Miyazawa, Keisuke; Mizushima, Noboru; Mnich, Katarzyna; Mograbi, Baharia; Mohseni, Simin; Moita, Luis Ferreira; Molinari, Marco; Molinari, Maurizio; Møller, Andreas Buch; Mollereau, Bertrand; Mollinedo, Faustino; Mongillo, Marco; Monick, Martha M; Montagnaro, Serena; Montell, Craig; Moore, Darren J; Moore, Michael N; Mora-Rodriguez, Rodrigo; Moreira, Paula I; Morel, Etienne; Morelli, Maria Beatrice; Moreno, Sandra; Morgan, Michael J; Moris, Arnaud; Moriyasu, Yuji; Morrison, Janna L; Morrison, Lynda A; Morselli, Eugenia; Moscat, Jorge; Moseley, Pope L; Mostowy, Serge; Motori, Elisa; Mottet, Denis; Mottram, Jeremy C; Moussa, Charbel E-H; Mpakou, Vassiliki E; Mukhtar, Hasan; Mulcahy Levy, Jean M; Muller, Sylviane; Muñoz-Moreno, Raquel; Muñoz-Pinedo, Cristina; Münz, Christian; Murphy, Maureen E; Murray, James T; Murthy, Aditya; Mysorekar, Indira U; Nabi, Ivan R; Nabissi, Massimo; Nader, Gustavo A; Nagahara, Yukitoshi; Nagai, Yoshitaka; Nagata, Kazuhiro; Nagelkerke, Anika; Nagy, Péter; Naidu, Samisubbu R; Nair, Sreejayan; Nakano, Hiroyasu; Nakatogawa, Hitoshi; Nanjundan, Meera; Napolitano, Gennaro; Naqvi, Naweed I; Nardacci, Roberta; Narendra, Derek P; Narita, Masashi; Nascimbeni, Anna Chiara; Natarajan, Ramesh; Navegantes, Luiz C; Nawrocki, Steffan T; Nazarko, Taras Y; Nazarko, Volodymyr Y; Neill, Thomas; Neri, Luca M; Netea, Mihai G; Netea-Maier, Romana T; Neves, Bruno M; Ney, Paul A; Nezis, Ioannis P; Nguyen, Hang Tt; Nguyen, Huu Phuc; Nicot, Anne-Sophie; Nilsen, Hilde; Nilsson, Per; Nishimura, Mikio; Nishino, Ichizo; Niso-Santano, Mireia; Niu, Hua; Nixon, Ralph A; Njar, Vincent Co; Noda, Takeshi; Noegel, Angelika A; Nolte, Elsie Magdalena; Norberg, Erik; Norga, Koenraad K; Noureini, Sakineh Kazemi; Notomi, Shoji; Notterpek, Lucia; Nowikovsky, Karin; Nukina, Nobuyuki; Nürnberger, Thorsten; O'Donnell, Valerie B; O'Donovan, Tracey; O'Dwyer, Peter J; Oehme, Ina; Oeste, Clara L; Ogawa, Michinaga; Ogretmen, Besim; Ogura, Yuji; Oh, Young J; Ohmuraya, Masaki; Ohshima, Takayuki; Ojha, Rani; Okamoto, Koji; Okazaki, Toshiro; Oliver, F Javier; Ollinger, Karin; Olsson, Stefan; Orban, Daniel P; Ordonez, Paulina; Orhon, Idil; Orosz, Laszlo; O'Rourke, Eyleen J; Orozco, Helena; Ortega, Angel L; Ortona, Elena; Osellame, Laura D; Oshima, Junko; Oshima, Shigeru; Osiewacz, Heinz D; Otomo, Takanobu; Otsu, Kinya; Ou, Jing-Hsiung James; Outeiro, Tiago F; Ouyang, Dong-Yun; Ouyang, Hongjiao; Overholtzer, Michael; Ozbun, Michelle A; Ozdinler, P Hande; Ozpolat, Bulent; Pacelli, Consiglia; Paganetti, Paolo; Page, Guylène; Pages, Gilles; Pagnini, Ugo; Pajak, Beata; Pak, Stephen C; Pakos-Zebrucka, Karolina; Pakpour, Nazzy; Palková, Zdena; Palladino, Francesca; Pallauf, Kathrin; Pallet, Nicolas; Palmieri, Marta; Paludan, Søren R; Palumbo, Camilla; Palumbo, Silvia; Pampliega, Olatz; Pan, Hongming; Pan, Wei; Panaretakis, Theocharis; Pandey, Aseem; Pantazopoulou, Areti; Papackova, Zuzana; Papademetrio, Daniela L; Papassideri, Issidora; Papini, Alessio; Parajuli, Nirmala; Pardo, Julian; Parekh, Vrajesh V; Parenti, Giancarlo; Park, Jong-In; Park, Junsoo; Park, Ohkmae K; Parker, Roy; Parlato, Rosanna; Parys, Jan B; Parzych, Katherine R; Pasquet, Jean-Max; Pasquier, Benoit; Pasumarthi, Kishore Bs; Patschan, Daniel; Patterson, Cam; Pattingre, Sophie; Pattison, Scott; Pause, Arnim; Pavenstädt, Hermann; Pavone, Flaminia; Pedrozo, Zully; Peña, Fernando J; Peñalva, Miguel A; Pende, Mario; Peng, Jianxin; Penna, Fabio; Penninger, Josef M; Pensalfini, Anna; Pepe, Salvatore; Pereira, Gustavo Js; Pereira, Paulo C; Pérez-de la Cruz, Verónica; Pérez-Pérez, María Esther; Pérez-Rodríguez, Diego; Pérez-Sala, Dolores; Perier, Celine; Perl, Andras; Perlmutter, David H; Perrotta, Ida; Pervaiz, Shazib; Pesonen, Maija; Pessin, Jeffrey E; Peters, Godefridus J; Petersen, Morten; Petrache, Irina; Petrof, Basil J; Petrovski, Goran; Phang, James M; Piacentini, Mauro; Pierdominici, Marina; Pierre, Philippe; Pierrefite-Carle, Valérie; Pietrocola, Federico; Pimentel-Muiños, Felipe X; Pinar, Mario; Pineda, Benjamin; Pinkas-Kramarski, Ronit; Pinti, Marcello; Pinton, Paolo; Piperdi, Bilal; Piret, James M; Platanias, Leonidas C; Platta, Harald W; Plowey, Edward D; Pöggeler, Stefanie; Poirot, Marc; Polčic, Peter; Poletti, Angelo; Poon, Audrey H; Popelka, Hana; Popova, Blagovesta; Poprawa, Izabela; Poulose, Shibu M; Poulton, Joanna; Powers, Scott K; Powers, Ted; Pozuelo-Rubio, Mercedes; Prak, Krisna; Prange, Reinhild; Prescott, Mark; Priault, Muriel; Prince, Sharon; Proia, Richard L; Proikas-Cezanne, Tassula; Prokisch, Holger; Promponas, Vasilis J; Przyklenk, Karin; Puertollano, Rosa; Pugazhenthi, Subbiah; Puglielli, Luigi; Pujol, Aurora; Puyal, Julien; Pyeon, Dohun; Qi, Xin; Qian, Wen-Bin; Qin, Zheng-Hong; Qiu, Yu; Qu, Ziwei; Quadrilatero, Joe; Quinn, Frederick; Raben, Nina; Rabinowich, Hannah; Radogna, Flavia; Ragusa, Michael J; Rahmani, Mohamed; Raina, Komal; Ramanadham, Sasanka; Ramesh, Rajagopal; Rami, Abdelhaq; Randall-Demllo, Sarron; Randow, Felix; Rao, Hai; Rao, V Ashutosh; Rasmussen, Blake B; Rasse, Tobias M; Ratovitski, Edward A; Rautou, Pierre-Emmanuel; Ray, Swapan K; Razani, Babak; Reed, Bruce H; Reggiori, Fulvio; Rehm, Markus; Reichert, Andreas S; Rein, Theo; Reiner, David J; Reits, Eric; Ren, Jun; Ren, Xingcong; Renna, Maurizio; Reusch, Jane Eb; Revuelta, Jose L; Reyes, Leticia; Rezaie, Alireza R; Richards, Robert I; Richardson, Des R; Richetta, Clémence; Riehle, Michael A; Rihn, Bertrand H; Rikihisa, Yasuko; Riley, Brigit E; Rimbach, Gerald; Rippo, Maria Rita; Ritis, Konstantinos; Rizzi, Federica; Rizzo, Elizete; Roach, Peter J; Robbins, Jeffrey; Roberge, Michel; Roca, Gabriela; Roccheri, Maria Carmela; Rocha, Sonia; Rodrigues, Cecilia Mp; Rodríguez, Clara I; de Cordoba, Santiago Rodriguez; Rodriguez-Muela, Natalia; Roelofs, Jeroen; Rogov, Vladimir V; Rohn, Troy T; Rohrer, Bärbel; Romanelli, Davide; Romani, Luigina; Romano, Patricia Silvia; Roncero, M Isabel G; Rosa, Jose Luis; Rosello, Alicia; Rosen, Kirill V; Rosenstiel, Philip; Rost-Roszkowska, Magdalena; Roth, Kevin A; Roué, Gael; Rouis, Mustapha; Rouschop, Kasper M; Ruan, Daniel T; Ruano, Diego; Rubinsztein, David C; Rucker, Edmund B; Rudich, Assaf; Rudolf, Emil; Rudolf, Ruediger; Ruegg, Markus A; Ruiz-Roldan, Carmen; Ruparelia, Avnika Ashok; Rusmini, Paola; Russ, David W; Russo, Gian Luigi; Russo, Giuseppe; Russo, Rossella; Rusten, Tor Erik; Ryabovol, Victoria; Ryan, Kevin M; Ryter, Stefan W; Sabatini, David M; Sacher, Michael; Sachse, Carsten; Sack, Michael N; Sadoshima, Junichi; Saftig, Paul; Sagi-Eisenberg, Ronit; Sahni, Sumit; Saikumar, Pothana; Saito, Tsunenori; Saitoh, Tatsuya; Sakakura, Koichi; Sakoh-Nakatogawa, Machiko; Sakuraba, Yasuhito; Salazar-Roa, María; Salomoni, Paolo; Saluja, Ashok K; Salvaterra, Paul M; Salvioli, Rosa; Samali, Afshin; Sanchez, Anthony Mj; Sánchez-Alcázar, José A; Sanchez-Prieto, Ricardo; Sandri, Marco; Sanjuan, Miguel A; Santaguida, Stefano; Santambrogio, Laura; Santoni, Giorgio; Dos Santos, Claudia Nunes; Saran, Shweta; Sardiello, Marco; Sargent, Graeme; Sarkar, Pallabi; Sarkar, Sovan; Sarrias, Maria Rosa; Sarwal, Minnie M; Sasakawa, Chihiro; Sasaki, Motoko; Sass, Miklos; Sato, Ken; Sato, Miyuki; Satriano, Joseph; Savaraj, Niramol; Saveljeva, Svetlana; Schaefer, Liliana; Schaible, Ulrich E; Scharl, Michael; Schatzl, Hermann M.; Schekman, Randy; Scheper, Wiep; Schiavi, Alfonso; Schipper, Hyman M; Schmeisser, Hana; Schmidt, Jens; Schmitz, Ingo; Schneider, Bianca E; Schneider, E Marion; Schneider, Jaime L; Schon, Eric A; Schönenberger, Miriam J; Schönthal, Axel H; Schorderet, Daniel F; Schröder, Bernd; Schuck, Sebastian; Schulze, Ryan J; Schwarten, Melanie; Schwarz, Thomas L; Sciarretta, Sebastiano; Scotto, Kathleen; Scovassi, A Ivana; Screaton, Robert A; Screen, Mark; Seca, Hugo; Sedej, Simon; Segatori, Laura; Segev, Nava; Seglen, Per O; Seguí-Simarro, Jose M; Segura-Aguilar, Juan; Seki, Ekihiro; Seiliez, Iban; Sell, Christian; Semenkovich, Clay F; Semenza, Gregg L; Sen, Utpal; Serra, Andreas L; Serrano-Puebla, Ana; Sesaki, Hiromi; Setoguchi, Takao; Settembre, Carmine; Shacka, John J; Shajahan-Haq, Ayesha N; Shapiro, Irving M; Sharma, Shweta; She, Hua; Shen, C-K James; Shen, Chiung-Chyi; Shen, Han-Ming; Shen, Sanbing; Shen, Weili; Sheng, Rui; Sheng, Xianyong; Sheng, Zu-Hang; Shepherd, Trevor G; Shi, Junyan; Shi, Qiang; Shi, Qinghua; Shi, Yuguang; Shibutani, Shusaku; Shibuya, Kenichi; Shidoji, Yoshihiro; Shieh, Jeng-Jer; Shih, Chwen-Ming; Shimada, Yohta; Shimizu, Shigeomi; Shin, Dong Wook; Shinohara, Mari L; Shintani, Michiko; Shintani, Takahiro; Shioi, Tetsuo; Shirabe, Ken; Shiri-Sverdlov, Ronit; Shirihai, Orian; Shore, Gordon C; Shu, Chih-Wen; Shukla, Deepak; Sibirny, Andriy A; Sica, Valentina; Sigurdson, Christina J; Sigurdsson, Einar M; Sijwali, Puran Singh; Sikorska, Beata; Silveira, Wilian A; Silvente-Poirot, Sandrine; Silverman, Gary A; Simak, Jan; Simmet, Thomas; Simon, Anna Katharina; Simon, Hans-Uwe; Simone, Cristiano; Simons, Matias; Simonsen, Anne; Singh, Rajat; Singh, Shivendra V; Singh, Shrawan K; Sinha, Debasish; Sinha, Sangita; Sinicrope, Frank A; Sirko, Agnieszka; Sirohi, Kapil; Sishi, Balindiwe Jn; Sittler, Annie; Siu, Parco M; Sivridis, Efthimios; Skwarska, Anna; Slack, Ruth; Slaninová, Iva; Slavov, Nikolai; Smaili, Soraya S; Smalley, Keiran Sm; Smith, Duncan R; Soenen, Stefaan J; Soleimanpour, Scott A; Solhaug, Anita; Somasundaram, Kumaravel; Son, Jin H; Sonawane, Avinash; Song, Chunjuan; Song, Fuyong; Song, Hyun Kyu; Song, Ju-Xian; Song, Wei; Soo, Kai Y; Sood, Anil K; Soong, Tuck Wah; Soontornniyomkij, Virawudh; Sorice, Maurizio; Sotgia, Federica; Soto-Pantoja, David R; Sotthibundhu, Areechun; Sousa, Maria João; Spaink, Herman P; Span, Paul N; Spang, Anne; Sparks, Janet D; Speck, Peter G; Spector, Stephen A; Spies, Claudia D; Springer, Wolfdieter; Clair, Daret St; Stacchiotti, Alessandra; Staels, Bart; Stang, Michael T; Starczynowski, Daniel T; Starokadomskyy, Petro; Steegborn, Clemens; Steele, John W; Stefanis, Leonidas; Steffan, Joan; Stellrecht, Christine M; Stenmark, Harald; Stepkowski, Tomasz M; Stern, Stęphan T; Stevens, Craig; Stockwell, Brent R; Stoka, Veronika; 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Tanaka, Masaki; Tang, Daolin; Tang, Dingzhong; Tang, Guomei; Tanida, Isei; Tanji, Kunikazu; Tannous, Bakhos A; Tapia, Jose A; Tasset-Cuevas, Inmaculada; Tatar, Marc; Tavassoly, Iman; Tavernarakis, Nektarios; Taylor, Allen; Taylor, Graham S; Taylor, Gregory A; Taylor, J Paul; Taylor, Mark J; Tchetina, Elena V; Tee, Andrew R; Teixeira-Clerc, Fatima; Telang, Sucheta; Tencomnao, Tewin; Teng, Ba-Bie; Teng, Ru-Jeng; Terro, Faraj; Tettamanti, Gianluca; Theiss, Arianne L; Theron, Anne E; Thomas, Kelly Jean; Thomé, Marcos P; Thomes, Paul G; Thorburn, Andrew; Thorner, Jeremy; Thum, Thomas; Thumm, Michael; Thurston, Teresa Lm; Tian, Ling; Till, Andreas; Ting, Jenny Pan-Yun; Titorenko, Vladimir I; Toker, Lilach; Toldo, Stefano; Tooze, Sharon A; Topisirovic, Ivan; Torgersen, Maria Lyngaas; Torosantucci, Liliana; Torriglia, Alicia; Torrisi, Maria Rosaria; Tournier, Cathy; Towns, Roberto; Trajkovic, Vladimir; Travassos, Leonardo H; Triola, Gemma; Tripathi, Durga Nand; Trisciuoglio, Daniela; Troncoso, Rodrigo; Trougakos, Ioannis P; Truttmann, Anita C; Tsai, Kuen-Jer; Tschan, Mario P; Tseng, Yi-Hsin; Tsukuba, Takayuki; Tsung, Allan; Tsvetkov, Andrey S; Tu, Shuiping; Tuan, Hsing-Yu; Tucci, Marco; Tumbarello, David A; Turk, Boris; Turk, Vito; Turner, Robin Fb; Tveita, Anders A; Tyagi, Suresh C; Ubukata, Makoto; Uchiyama, Yasuo; Udelnow, Andrej; Ueno, Takashi; Umekawa, Midori; Umemiya-Shirafuji, Rika; Underwood, Benjamin R; Ungermann, Christian; Ureshino, Rodrigo P; Ushioda, Ryo; Uversky, Vladimir N; Uzcátegui, Néstor L; Vaccari, Thomas; Vaccaro, Maria I; Váchová, Libuše; Vakifahmetoglu-Norberg, Helin; Valdor, Rut; Valente, Enza Maria; Vallette, Francois; Valverde, Angela M; Van den Berghe, Greet; Van Den Bosch, Ludo; van den Brink, Gijs R; van der Goot, F Gisou; van der Klei, Ida J; van der Laan, Luc Jw; van Doorn, Wouter G; van Egmond, Marjolein; van Golen, Kenneth L; Van Kaer, Luc; van Lookeren Campagne, Menno; Vandenabeele, Peter; Vandenberghe, Wim; Vanhorebeek, Ilse; Varela-Nieto, Isabel; Vasconcelos, M Helena; Vasko, Radovan; Vavvas, Demetrios G; Vega-Naredo, Ignacio; Velasco, Guillermo; Velentzas, Athanassios D; Velentzas, Panagiotis D; Vellai, Tibor; Vellenga, Edo; Vendelbo, Mikkel Holm; Venkatachalam, Kartik; Ventura, Natascia; Ventura, Salvador; Veras, Patrícia St; Verdier, Mireille; Vertessy, Beata G; Viale, Andrea; Vidal, Michel; Vieira, Helena LA; Vierstra, Richard D; Vigneswaran, Nadarajah; Vij, Neeraj; Vila, Miquel; Villar, Margarita; Villar, Victor H; Villarroya, Joan; Vindis, Cécile; Viola, Giampietro; Viscomi, Maria Teresa; Vitale, Giovanni; Vogl, Dan T; Voitsekhovskaja, Olga V; von Haefen, Clarissa; von Schwarzenberg, Karin; Voth, Daniel E; Vouret-Craviari, Valérie; Vuori, Kristina; Vyas, Jatin M; Waeber, Christian; Walker, Cheryl Lyn; Walker, Mark J; Walter, Jochen; Wan, Lei; Wan, Xiangbo; Wang, Bo; Wang, Caihong; Wang, Chao-Yung; Wang, Chengshu; Wang, Chenran; Wang, Chuangui; Wang, Dong; Wang, Fen; Wang, Fuxin; Wang, Guanghui; Wang, Hai-Jie; Wang, Haichao; Wang, Hong-Gang; Wang, Hongmin; Wang, Horng-Dar; Wang, Jing; Wang, Junjun; Wang, Mei; Wang, Mei-Qing; Wang, Pei-Yu; Wang, Peng; Wang, Richard C; Wang, Shuo; Wang, Ting-Fang; Wang, Xian; Wang, Xiao-Jia; Wang, Xiao-Wei; Wang, Xin; Wang, Xuejun; Wang, Yan; Wang, Yanming; Wang, Ying; Wang, Ying-Jan; Wang, Yipeng; Wang, Yu; Wang, Yu Tian; Wang, Yuqing; Wang, Zhi-Nong; Wappner, Pablo; Ward, Carl; Ward, Diane McVey; Warnes, Gary; Watada, Hirotaka; Watanabe, Yoshihisa; Watase, Kei; Weaver, Timothy E; Weekes, Colin D; Wei, Jiwu; Weide, Thomas; Weihl, Conrad C; Weindl, Günther; Weis, Simone Nardin; Wen, Longping; Wen, Xin; Wen, Yunfei; Westermann, Benedikt; Weyand, Cornelia M; White, Anthony R; White, Eileen; Whitton, J Lindsay; Whitworth, Alexander J; Wiels, Joëlle; Wild, Franziska; Wildenberg, Manon E; Wileman, Tom; Wilkinson, Deepti Srinivas; Wilkinson, Simon; Willbold, Dieter; Williams, Chris; Williams, Katherine; Williamson, Peter R; Winklhofer, Konstanze F; Witkin, Steven S; Wohlgemuth, Stephanie E; Wollert, Thomas; Wolvetang, Ernst J; Wong, Esther; Wong, G William; Wong, Richard W; Wong, Vincent Kam Wai; Woodcock, Elizabeth A; Wright, Karen L; Wu, Chunlai; Wu, Defeng; Wu, Gen Sheng; Wu, Jian; Wu, Junfang; Wu, Mian; Wu, Min; Wu, Shengzhou; Wu, William Kk; Wu, Yaohua; Wu, Zhenlong; Xavier, Cristina Pr; Xavier, Ramnik J; Xia, Gui-Xian; Xia, Tian; Xia, Weiliang; Xia, Yong; Xiao, Hengyi; Xiao, Jian; Xiao, Shi; Xiao, Wuhan; Xie, Chuan-Ming; Xie, Zhiping; Xie, Zhonglin; Xilouri, Maria; Xiong, Yuyan; Xu, Chuanshan; Xu, Congfeng; Xu, Feng; Xu, Haoxing; Xu, Hongwei; Xu, Jian; Xu, Jianzhen; Xu, Jinxian; Xu, Liang; Xu, Xiaolei; Xu, Yangqing; Xu, Ye; Xu, Zhi-Xiang; Xu, Ziheng; Xue, Yu; Yamada, Takahiro; Yamamoto, Ai; Yamanaka, Koji; Yamashina, Shunhei; Yamashiro, Shigeko; Yan, Bing; Yan, Bo; Yan, Xianghua; Yan, Zhen; Yanagi, Yasuo; Yang, Dun-Sheng; Yang, Jin-Ming; Yang, Liu; Yang, Minghua; Yang, Pei-Ming; Yang, Peixin; Yang, Qian; Yang, Wannian; Yang, Wei Yuan; Yang, Xuesong; Yang, Yi; Yang, Ying; Yang, Zhifen; Yang, Zhihong; Yao, Meng-Chao; Yao, Pamela J; Yao, Xiaofeng; Yao, Zhenyu; Yao, Zhiyuan; Yasui, Linda S; Ye, Mingxiang; Yedvobnick, Barry; Yeganeh, Behzad; Yeh, Elizabeth S; Yeyati, Patricia L; Yi, Fan; Yi, Long; Yin, Xiao-Ming; Yip, Calvin K; Yoo, Yeong-Min; Yoo, Young Hyun; Yoon, Seung-Yong; Yoshida, Ken-Ichi; Yoshimori, Tamotsu; Young, Ken H; Yu, Huixin; Yu, Jane J; Yu, Jin-Tai; Yu, Jun; Yu, Li; Yu, W Haung; Yu, Xiao-Fang; Yu, Zhengping; Yuan, Junying; Yuan, Zhi-Min; Yue, Beatrice Yjt; Yue, Jianbo; Yue, Zhenyu; Zacks, David N; Zacksenhaus, Eldad; Zaffaroni, Nadia; Zaglia, Tania; Zakeri, Zahra; Zecchini, Vincent; Zeng, Jinsheng; Zeng, Min; Zeng, Qi; Zervos, Antonis S; Zhang, Donna D; Zhang, Fan; Zhang, Guo; Zhang, Guo-Chang; Zhang, Hao; Zhang, Hong; Zhang, Hong; Zhang, Hongbing; Zhang, Jian; Zhang, Jian; Zhang, Jiangwei; Zhang, Jianhua; Zhang, Jing-Pu; Zhang, Li; Zhang, Lin; Zhang, Lin; Zhang, Long; Zhang, Ming-Yong; Zhang, Xiangnan; Zhang, Xu Dong; Zhang, Yan; Zhang, Yang; Zhang, Yanjin; Zhang, Yingmei; Zhang, Yunjiao; Zhao, Mei; Zhao, Wei-Li; Zhao, Xiaonan; Zhao, Yan G; Zhao, Ying; Zhao, Yongchao; Zhao, Yu-Xia; Zhao, Zhendong; Zhao, Zhizhuang J; Zheng, Dexian; Zheng, Xi-Long; Zheng, Xiaoxiang; Zhivotovsky, Boris; Zhong, Qing; Zhou, Guang-Zhou; Zhou, Guofei; Zhou, Huiping; Zhou, Shu-Feng; Zhou, Xu-Jie; Zhu, Hongxin; Zhu, Hua; Zhu, Wei-Guo; Zhu, Wenhua; Zhu, Xiao-Feng; Zhu, Yuhua; Zhuang, Shi-Mei; Zhuang, Xiaohong; Ziparo, Elio; Zois, Christos E; Zoladek, Teresa; Zong, Wei-Xing; Zorzano, Antonio; Zughaier, Susu M
Guidelines for the use and interpretation of assays for monitoring autophagy. (3rd edition)
in Autophagy volume 12 (2016) issue 1. - page 1-222
doi:10.1080/15548627.2015.1100356 ...

Suenkel, Benjamin; Steegborn, Clemens
Recombinant Preparation, Biochemical Analysis, and Structure Determination of Sirtuin Family Hi ...
Enzymes of epigenetics. Part A
Cambridge, MA : Academic Press, 2016. - page 183-208 . - (Methods in Enzymology; 573)
doi:10.1016/bs.mie.2015.12.004 ...

Quinti, Luisa; Casale, Malcolm; Moniot, Sébastien; Pais, Teresa Faria; van Kanegan, Michael J.; Kaltenbach, Linda S.; Pallos, Judit; Lim, Ryan G.; Naidu, Sharadha Dayalan; Runne, Heike; Meisel, Lisa; Rauf, Nazifa Abdul; Leyfer, Dmitriy; Maxwell, Michelle M.; Saiah, Eddine; Landers, John E.; Luthi-Carter, Ruth; Abagyan, Ruben; Dinkova-Kostova, Albena T.; Steegborn, Clemens; Marsh, J. Lawrence; Lo, Donald C.; Thompson, Leslie M.; Kazantsev, Aleksey G.
SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington' ...
in Cell Chemical Biology volume 23 (2016) issue 7. - page 849-861
doi:10.1016/j.chembiol.2016.05.015 ...

Gertz, Melanie; Steegborn, Clemens
Using mitochondrial sirtuins as drug targets : disease implications and available compounds
in Cellular and Molecular Life Sciences volume 73 (2016) . - page 2871-2896
doi:10.1007/s00018-016-2180-7 ...

2015

Simic, Zeljko; Weiwad, Matthias; Schierhorn, Angelika; Steegborn, Clemens; Schutkowski, Mike
The ɛ-Amino Group of Protein Lysine Residues Is Highly Susceptible to Nonenzymatic Acylation by ...
in ChemBioChem volume 16 (2015) issue 16. - page 2337-2347
doi:10.1002/cbic.201500364 ...

di Fruscia, Paolo; Zacharioudakis, Emmanouil; Liu, Chang; Moniot, Sébastien; Laohasinnarong, Sasiwan; Khongkow, Mattaka; Harrison, Ian F.; Koltsida, Konstantina; Reynolds, Christopher R.; Schmidtkunz, Karin; Jung, Manfred; Chapman, Kathryn L.; Steegborn, Clemens; Dexter, David T.; Sternberg, Michael J. E.; Lam, Eric W.-F.; Fuchter, Matthew J.
The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-on ...
in ChemMedChem volume 10 (2015) issue 1. - page 69-82
doi:10.1002/cmdc.201402431 ...

Schweizer, Ulrich; Steegborn, Clemens
New insights into the structure and mechanism of iodothyronine deiodinases
in Journal of Molecular Endocrinology volume 55 (2015) issue 3. - page R37-R52
doi:10.1530/JME-15-0156 ...

Roessler, Claudia; Tüting, Christian; Meleshin, Marat; Steegborn, Clemens; Schutkowski, Mike
A Novel Continuous Assay for the Deacylase Sirtuin 5 and Other Deacetylases
in Journal of Medicinal Chemistry volume 58 (2015) issue 18. - page 7217-7223
doi:10.1021/acs.jmedchem.5b00293 ...

Fränzel, Benjamin; Fischer, Frank; Steegborn, Clemens; Wolters, Dirk
Proteinase K improves quantitative acylation studies
in Proteomics volume 15 (2015) issue 1. - page 44-47
doi:10.1002/pmic.201400015 ...

Rumpf, Tobias; Schiedel, Matthias; Karaman, Berin; Roessler, Claudia; North, Brian J.; Lehotzky, Attila; Oláh, Judit; Ladwein, Kathrin I.; Schmidtkunz, Karin; Gajer, Markus; Pannek, Martin; Steegborn, Clemens; Sinclair, David A.; Gerhardt, Stefan; Ovádi, Judit; Schutkowski, Mike; Sippl, Wolfgang; Einsle, Oliver; Jung, Manfred
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
in Nature Communications volume 6 (2015) . - page 6263
doi:10.1038/ncomms7263 ...

Chen, Xiqun; Wales, Pauline; Quinti, Luisa; Zuo, Fuxing; Moniot, Sébastien; Herisson, Fanny; Rauf, Nazifa Abdul; Wang, Hua; Silverman, Richard B.; Ayata, Cenk; Maxwell, Michelle M.; Steegborn, Clemens; Schwarzschild, Michael A.; Outeiro, Tiago F.; Kazantsev, Aleksey G.
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotro ...
in PLoS One volume 10 (2015) issue 1
doi:10.1371/journal.pone.0116919 ...

Polletta, Lucia; Vernucci, Enza; Carnevale, Ilaria; Arcangeli, Tania; Rotili, Dante; Palmerio, Silvia; Steegborn, Clemens; Nowak, Theresa; Schutkowski, Mike; Pellegrini, Laura; Sansone, Luigi; Villanova, Lidia; Runci, Alessandra; Pucci, Bruna; Morgante, Emanuela; Fini, Massimo; Mai, Antonello; Russo, Matteo A.; Tafani, Marco
SIRT5 regulation of ammonia-induced autophagy and mitophagy
in Autophagy volume 11 (2015) issue 2. - page 253-270
doi:10.1080/15548627.2015.1009778 ...

Schweizer, Ulrich; Steegborn, Clemens
Thyroid hormones : From Crystal Packing to Activity to Reactivity
in Angewandte Chemie International Edition volume 54 (2015) issue 44. - page 12856-12858
doi:10.1002/anie.201506919 ...

Banerjee, Arka; Adolph, Ramona S.; Gopalakrishnapai, Jayashree; Kleinbölting, Silke; Emmerich, Christiane; Steegborn, Clemens; Visweswariah, Sandhya S.
A Universal Stress Protein (USP) in Mycobacteria binds cAMP
in The Journal of Biological Chemistry volume 290 (2015) issue 20. - page 12731-12743
doi:10.1074/jbc.M115.644856 ...

2014

Schutkowski, Mike; Fischer, Frank; Roessler, Claudia; Steegborn, Clemens
New assays and approaches for discovery and design of Sirtuin modulators.
in Expert Opinion on Drug Discovery volume 9 (2014) issue 2. - page 183-199
doi:10.1517/17460441.2014.875526 ...

Schweizer, Ulrich; Schlicker, Christine; Braun, Doreen; Köhrle, Josef; Steegborn, Clemens
Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a per ...
in Proceedings of the National Academy of Sciences of the United States of America volume 111 (2014) issue 29. - page 10526-10531
doi:10.1073/pnas.1323873111 ...

Kleinbölting, Silke; Diaz, Ana; Moniot, Sébastien; van den Heuvel, Joop; Weyand, Michael; Levin, Lonny R.; Buck, Jochen; Steegborn, Clemens
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its ...
in Proceedings of the National Academy of Sciences of the United States of America volume 111 (2014) issue 10. - page 3727-3732
doi:10.1073/pnas.1322778111 ...

Suhre, Michael H.; Scheibel, Thomas; Steegborn, Clemens; Gertz, Melanie
Crystallization and preliminary X-ray diffractionanalysis of proximal thread matrix protein 1(P ...
in Acta Crystallographica Section F volume 70 (2014) issue 6. - page 769-772
doi:10.1107/S2053230X14006165 ...

Kleinbölting, Silke; van den Heuvel, Joop; Kambach, Christian; Weyand, Michael; Leipelt, Martina; Steegborn, Clemens
Expression, purification, crystallization and preliminary X-ray diffraction analysis of a mamma ...
in Acta Crystallographica Section F volume 70 (2014) issue 4. - page 467-469
doi:10.1107/S2053230X14004014 ...

Kleinbölting, Silke; van den Heuvel, Joop; Steegborn, Clemens
Structural analysis of human soluble adenylyl cyclase and crystal structures of its nucleotide ...
in The FEBS Journal volume 281 (2014) issue 18. - page 4151-4164
doi:10.1111/febs.12913 ...

Suhre, Michael H.; Gertz, Melanie; Steegborn, Clemens; Scheibel, Thomas
Structural and functional features of a collagen-binding matrix protein from the mussel byssus
in Nature Communications volume 5 (2014)
doi:10.1038/ncomms4392 ...

Steegborn, Clemens
Structure, mechanism, and regulation of soluble adenylyl cyclases : similarities and difference ...
in Biochimica et Biophysica Acta : Molecular Basis of Disease volume 1842 (2014) issue 12, Part B. - page 2535-2547
doi:10.1016/j.bbadis.2014.08.012 ...

Roessler, Claudia; Nowak, Theresa; Pannek, Martin; Gertz, Melanie; Nguyen, Giang Thi Tuyet; Scharfe, Michael; Born, Ilona; Sippl, Wolfgang; Steegborn, Clemens; Schutkowski, Mike
Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and ...
in Angewandte Chemie International Edition volume 53 (2014) issue 40. - page 10728-10732
doi:10.1002/anie.201402679 ...

2013

Rauh, David; Fischer, Frank; Gertz, Melanie; Lakshminarasimhan, Mahadevan; Bergbrede, Tim; Aladini, Firouzeh; Kambach, Christian; Becker, Christian F. W.; Zerweck, Johannes; Schutkowski, Mike; Steegborn, Clemens
An acetylome peptide microarray reveals specificities and deacetylation substrates for all huma ...
in Nature Communications volume 4 (2013) . - page 2327
doi:10.1038/ncomms3327 ...

Moniot, Sébastien; Schutkowski, Mike; Steegborn, Clemens
Crystal structure analysis of human Sirt2 and its ADP-ribose complex
in Journal of Structural Biology volume 182 (2013) issue 2. - page 136-143
doi:10.1016/j.jsb.2013.02.012 ...

Nguyen, Giang Thi Tuyet; Gertz, Melanie; Steegborn, Clemens
Crystal structures of Sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibi ...
in Chemistry & Biology volume 20 (2013) issue 11. - page 1375-1385
doi:10.1016/j.chembiol.2013.09.019 ...

Gertz, Melanie; Fischer, Frank; Nguyen, Giang Thi Tuyet; Lakshminarasimhan, Mahadevan; Schutkowski, Mike; Weyand, Michael; Steegborn, Clemens
Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism
in Proceedings of the National Academy of Sciences of the United States of America volume 110 (2013) issue 30
doi:10.1073/pnas.1303628110 ...

Suenkel, Benjamin; Fischer, Frank; Steegborn, Clemens
Inhibition of the human deacylase Sirtuin 5 by the indole GW5074
in Bioorganic & Medicinal Chemistry Letters volume 23 (2013) issue 1. - page 143-146
doi:10.1016/j.bmcl.2012.10.136 ...

Lakshminarasimhan, Mahadevan; Curth, Ute; Moniot, Sébastien; Mosalaganti, Shyamal; Raunser, Stefan; Steegborn, Clemens
Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and re ...
in Bioscience Reports volume 33 (2013) issue 3. - page 395-404
doi:10.1042/BSR20120121 ...

Lakshminarasimhan, Mahadevan; Rauh, David; Schutkowski, Mike; Steegborn, Clemens
Sirt1 activation by resveratrol is substrate sequence-selective.
in Aging volume 5 (2013) issue 3. - page 151-154

Laurent, Gaëlle; German, Natalie J.; Saha, Asish K.; de Boer, Vincent C. J.; Davies, Michael; Koves, Timothy R.; Dephoure, Noah; Fischer, Frank; Boanca, Gina; Vaitheesvaran, Bhavapriya; Lovitch, Scott B.; Sharpe, Arlene H.; Kurland, Irwin J.; Steegborn, Clemens; Gygi, Steven P.; Muoio, Deborah M.; Ruderman, Neil B.; Haigis, Marcia C.
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA ...
in Molecular Cell volume 50 (2013) issue 5. - page 686-698
doi:10.1016/j.molcel.2013.05.012 ...

Nguyen, Giang Thi Tuyet; Schäfer, Susanne; Gertz, Melanie; Weyand, Michael; Steegborn, Clemens
Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: bindin ...
in Acta Crystallographica Section D volume 69 (2013) issue 8. - page 1423-1432
doi:10.1107/S0907444913015448 ...

2012

Topal, Hüsnü; Fulcher, Nanette B.; Bitterman, Jacob; Salazar, Eric; Buck, Jochen; Levin, Lonny R.; Cann, Martin J.; Wolfgang, Matthew C.; Steegborn, Clemens
Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathoge ...
in Journal of Molecular Biology volume 416 (2012) issue 2. - page 271-286
doi:10.1016/j.jmb.2011.12.045 ...

Middelhaufe, Sabine; Leipelt, Martina; Levin, Lonny R.; Buck, Jochen; Steegborn, Clemens
Identification of a haem domain in human soluble adenylate cyclase.
in Bioscience Reports volume 32 (2012) issue 5. - page 491-499
doi:10.1042/BSR20120051 ...

Gertz, Melanie; Nguyen, Giang Thi Tuyet; Fischer, Frank; Suenkel, Benjamin; Schlicker, Christine; Fränzel, Benjamin; Tomaschewski, Jana; Aladini, Firouzeh; Becker, Christian F. W.; Wolters, Dirk; Steegborn, Clemens
A molecular mechanism for direct sirtuin activation by resveratrol
in PLoS One volume 7 (2012) issue 11
doi:10.1371/journal.pone.0049761 ...

Fischer, Frank; Gertz, Melanie; Suenkel, Benjamin; Lakshminarasimhan, Mahadevan; Schutkowski, Mike; Steegborn, Clemens
Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition
in PLoS One volume 7 (2012) issue 9
doi:10.1371/journal.pone.0045098 ...

Moniot, Sébastien; Weyand, Michael; Steegborn, Clemens
Structures, substrates, and regulators of Mammalian sirtuins : opportunities and challenges for ...
in Frontiers in Pharmacology volume 3 (2012)
doi:10.3389/fphar.2012.00016 ...

2011

Russwurm, Michael; Schlicker, Christine; Weyand, Michael; Koesling, Doris; Steegborn, Clemens
Crystal structure of the GAF-B domain from human phosphodiesterase 5.
in Proteins volume 79 (2011) issue 5. - page 1682-1687
doi:10.1002/prot.22989 ...

Lakshminarasimhan, Mahadevan; Steegborn, Clemens
Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targets ...
in Experimental Gerontology volume 46 (2011) issue 2-3. - page 174-177
doi:10.1016/j.exger.2010.08.024 ...

Schlicker, Christine; Boanca, Gina; Lakshminarasimhan, Mahadevan; Steegborn, Clemens
Structure-based development of novel sirtuin inhibitors.
in Aging volume 3 (2011) issue 9. - page 852-872

Acin-Perez, Rebeca; Russwurm, Michael; Günnewig, Kathrin; Gertz, Melanie; Zoidl, Georg; Ramos, Lavoisier; Buck, Jochen; Levin, Lonny R.; Rassow, Joachim; Manfredi, Giovanni; Steegborn, Clemens
A phosphodiesterase 2A isoform localized to mitochondria regulates respiration
in The Journal of Biological Chemistry volume 286 (2011) issue 35. - page 30423-30432
doi:10.1074/jbc.M111.266379 ...

2010

Hall, Rebecca A.; de Sordi, Luisa; Maccallum, Donna M.; Topal, Hüsnü; Eaton, Rebecca; Bloor, James W.; Robinson, Gary K.; Levin, Lonny R.; Buck, Jochen; Wang, Yue; Gow, Neil A .R.; Steegborn, Clemens; Mühlschlegel, Fritz A.
CO₂ acts as a signalling molecule in populations of the fungal pathogen Candida albicans
in PLoS Pathogens volume 6 (2010) issue 11
doi:10.1371/journal.ppat.1001193 ...

Baur, Joseph A.; Chen, Danica; Chini, Eduardo N.; Chua, Katrin F.; Cohen, Haim Y.; de Cabo, Rafael; Deng, Chuxia; Dimmeler, Stefanie; Gius, David; Guarente, Leonard P.; Helfand, Stephen L.; Imai, Shin-Ichiro; Itoh, Hiroshi; Kadowaki, Takashi; Koya, Daisuke; Leeuwenburgh, Christiaan; McBurney, Michael; Nabeshima, Yo-Ichi; Neri, Christian; Oberdoerffer, Philipp; Pestell, Richard G.; Rogina, Blanka; Sadoshima, Junichi; Sartorelli, Vittorio; Serrano, Manuel; Sinclair, David A.; Steegborn, Clemens; Tatar, Marc; Tissenbaum, Heidi A.; Tong, Qiang; Tsubota, Kazuo; Vaquero, Alejandro; Verdin, Eric
Dietary restriction : standing up for sirtuins
in Science volume 329 (2010) issue 5995. - page 1012-1013
doi:10.1126/science.329.5995.1012 ...

Gertz, Melanie; Steegborn, Clemens
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia
in Biochimica et Biophysica Acta : Proteins and Proteomics volume 1804 (2010) issue 8. - page 1658-1665
doi:10.1016/j.bbapap.2009.09.011 ...

Gertz, Melanie; Steegborn, Clemens
The Lifespan-Regulator p66Shc in mitochondria : redox enzyme or redox sensor?
in Antioxidants & Redox Signaling volume 13 (2010) issue 9. - page 1417-1428
doi:10.1089/ars.2010.3147 ...

Gertz, Melanie; Steegborn, Clemens
The mitochondrial apoptosis pathway and p66Shc : a regulatory redox enzyme or an adapter protei ...
in Cell Cycle volume 9 (2010) issue 22. - page 4425-4426
doi:10.4161/cc.9.22.14053 ...

2009

Innocenti, Alessio; Hall, Rebecca A.; Schlicker, Christine; Scozzafava, Andrea; Steegborn, Clemens; Mühlschlegel, Fritz A.; Supuran, Claudiu T.
Carbonic anhydrase inhibitors : Inhibition and homology modeling studies of the fungal β-carbon ...
in Bioorganic & Medicinal Chemistry volume 17 (2009) issue 13. - page 4503-4509
doi:10.1016/j.bmc.2009.05.002 ...

Steegborn, Clemens; Ohndorf, Uta-Maria; Schlicker, Christine
Crystallographic studies on carbonic anhydrases from fungal pathogens for structure-assisted dr ...
Supuran, Claudiu T. ; Winum, J.-Y. (Hrsg.): Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural and Disease Applications.
Hoboken, NJ : Wiley, 2009. - page 323-334 . - (Wiley Series in Drug Discovery and Development)

Gertz, Melanie; Fischer, Frank; Leipelt, Martina; Wolters, Dirk; Steegborn, Clemens
Identification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator pro ...
in Aging volume 1 (2009) issue 2. - page 254-265
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC280600 ...

Schlicker, Christine; Hall, Rebecca A.; Vullo, Daniela; Middelhaufe, Sabine; Gertz, Melanie; Supuran, Claudiu T.; Mühlschlegel, Fritz A.; Steegborn, Clemens
Structure and inhibition of the CO₂-sensing carbonic anhydrase Can2 from the pathogenic fungus ...
in Journal of Molecular Biology volume 385 (2009) issue 4. - page 1207-1220
doi:10.1016/j.jmb.2008.11.037 ...

2008

Gertz, Melanie; Fischer, Frank; Wolters, Dirk; Steegborn, Clemens
Activation of the lifespan regulator p66Shc through reversible disulfide bond formation.
in Proceedings of the National Academy of Sciences of the United States of America volume 105 (2008) issue 15. - page 5705-5709
doi:10.1073/pnas.0800691105 ...

Innocenti, Alessio; Mühlschlegel, Fritz A.; Hall, Rebecca A.; Steegborn, Clemens; Scozzafava, Andrea; Supuran, Claudiu T.
Carbonic anhydrase inhibitors: inhibition of the β-class enzymes from the fungal pathogens Cand ...
in Bioorganic & Medicinal Chemistry Letters volume 18 (2008) issue 18. - page 5066-5070
doi:10.1016/j.bmcl.2008.07.122 ...

Rauch, Annika; Leipelt, Martina; Russwurm, Michael; Steegborn, Clemens
Crystal structure of the guanylyl cyclase Cya2
in Proceedings of the National Academy of Sciences of the United States of America volume 105 (2008) issue 41. - page 15720-15725
doi:10.1073/pnas.0808473105 ...

Tammenkoski, Marko; Koivula, Katja; Cusanelli, Emilio; Zollo, Massimo; Steegborn, Clemens; Baykov, Alexander A.; Lahti, Reijo
Human metastasis regulator protein H-prune is a short-chain exopolyphosphatase.
in Biochemistry volume 47 (2008) issue 36. - page 9707-9713
doi:10.1021/bi8010847 ...

Garzia, Livia; D'Angelo, A.; Amoresano, A.; Knauer, Shirley K.; Cirulli, C.; Campanella, C.; Stauber, R. H.; Steegborn, Clemens; Iolascon, A.; Zollo, Massimo
Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell ...
in Oncogene volume 27 (2008) . - page 1853-1864
doi:10.1038/sj.onc.1210822 ...

Schlicker, Christine; Rauch, Annika; Hess, Ken C.; Kachholz, Barbara; Levin, Lonny R.; Buck, Jochen; Steegborn, Clemens
Structure-based development of novel adenylyl cyclase inhibitors.
in Journal of Medicinal Chemistry volume 51 (2008) issue 15. - page 4456-4464
doi:10.1021/jm800481q ...

Schlicker, Christine; Gertz, Melanie; Papatheodorou, Panagiotis; Kachholz, Barbara; Becker, Christian F. W.; Steegborn, Clemens
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5
in Journal of Molecular Biology volume 382 (2008) issue 3. - page 790-801
doi:10.1016/j.jmb.2008.07.048 ...

2007

Middelhaufe, Sabine; Garzia, Livia; Ohndorf, Uta-Maria; Kachholz, Barbara; Zollo, Massimo; Steegborn, Clemens
Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerizat ...
in Biochemical Journal volume 407 (2007) issue 2. - page 199-205
doi:10.1042/BJ20070408 ...

Mannherz, Hans Georg; Ballweber, Edda; Galla, Marco; Villard, Sylvie; Granier, Claude; Steegborn, Clemens; Schmidtmann, Anja; Jaquet, Kornelia; Pope, Brian; Weeds, Alan G.
Mapping the ADF/cofilin binding site on monomeric actin by competitive cross-linking and peptid ...
in Journal of Molecular Biology volume 366 (2007) issue 3. - page 745-755
doi:10.1016/j.jmb.2006.11.100 ...

2006

Mogensen, Estelle Geweiss; Janbon, Guilhem; Chaloupka, James; Steegborn, Clemens; Fu, Man Shun; Moyrand, Frédérique; Klengel, Torsten; Pearson, David S.; Geeves, Michael A.; Buck, Jochen; Levin, Lonny R.; Mühlschlegel, Fritz A.
Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase ...
in Eukaryotic Cell volume 5 (2006) issue 1. - page 103-111
doi:10.1128/EC.5.1.103-111.2006 ...

Kamenetsky, Margarita; Middelhaufe, Sabine; Bank, Erin M.; Levin, Lonny R.; Buck, Jochen; Steegborn, Clemens
Molecular details of cAMP generation in mammalian cells : a tale of two systems.
in Journal of Molecular Biology volume 362 (2006) issue 4. - page 623-639
doi:10.1016/j.jmb.2006.07.045 ...

2005

Steegborn, Clemens; Litvin, Tatiana N.; Levin, Lonny R.; Buck, Jochen; Wu, Hao
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and m ...
in Nature Structural & Molecular Biology volume 12 (2005) issue 1. - page 32-37
doi:10.1038/nsmb880 ...

Steegborn, Clemens; Litvin, Tatiana N.; Hess, Kenneth C.; Capper, Austin B.; Taussig, Ronald; Buck, Jochen; Levin, Lonny R.; Wu, Hao
A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex wit ...
in The Journal of Biological Chemistry volume 280 (2005) issue 36. - page 31754-31759
doi:10.1074/jbc.M507144200 ...

2004

Ye, Hong; Chen, Tzu-Chao; Xu, Xiaohui; Pennycooke, Micha; Wu, Hao; Steegborn, Clemens
Crystal structure of the putative adapter protein MTH1859
in Journal of Structural Biology volume 148 (2004) issue 2. - page 251-256
doi:10.1016/j.jsb.2004.06.004 ...

2003

Augustin, Martin A.; Reichert, Andreas S.; Betat, Heike; Huber, Robert; Mörl, Mario; Steegborn, Clemens
Crystal structure of the human CCA-adding enzyme: insights into template-independent polymeriza ...
in Journal of Molecular Biology volume 328 (2003) issue 5. - page 985-994
doi:10.1016/S0022-2836(03)00381-4 ...

Messerschmidt, Albrecht; Worbs, Michael; Steegborn, Clemens; Wahl, Markus C.; Huber, Robert; Laber, Bernd; Clausen, Tim
Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: c ...
in Biological Chemistry volume 384 (2003) issue 3. - page 373-386
doi:10.1515/BC.2003.043 ...

Xu, Guozhou; Rich, Rebecca L.; Steegborn, Clemens; Min, Tongpil; Huang, Yihua; Myszka, David G.; Wu, Hao
Mutational analyses of the p35-caspase interaction : A bowstring kinetic model of caspase inhib ...
in The Journal of Biological Chemistry volume 278 (2003) issue 7. - page 5455-5461
doi:10.1074/jbc.M211607200 ...

2002

Stabler, Sally P.; Steegborn, Clemens; Wahl, Markus C.; Oliveriusova, Jana; Kraus, Jan P.; Allen, Robert H.; Wagner, Conrad; Mudd, S. Harvey
Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency.
in Metabolism volume 51 (2002) issue 8. - page 981-988
doi:10.1053/meta.2002.34017 ...

Rossoll, Wilfried; Kröning, Ann-Kathrin; Ohndorf, Uta-Maria; Steegborn, Clemens; Jablonka, Sibylle; Sendtner, Michael
Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R ...
in Human Molecular Genetics volume 11 (2002) issue 1. - page 93-105
doi:10.1093/hmg/11.1.93 ...

2001

Steegborn, Clemens; Laber, Bernd; Messerschmidt, Albrecht; Huber, Robert; Clausen, Tim
Crystal structures of cystathionine γ-synthase inhibitor complexes rationalize the increased af ...
in Journal of Molecular Biology volume 311 (2001) issue 4. - page 789-801
doi:10.1006/jmbi.2001.4880 ...

Ohndorf, Uta-Maria; Steegborn, Clemens; Knijff, Rainer; Sondermann, Peter
Contributions of the individual domains in human La protein to its RNA 3'-end binding activity
in The Journal of Biological Chemistry volume 276 (2001) issue 29. - page 27188-27196
doi:10.1074/jbc.M102891200 ...

Dorowski, Anja; Hofmann, Andreas; Steegborn, Clemens; Boicu, Marius; Huber, Robert
Crystal structure of paprika ferredoxin-NADP+ reductase : Implications for the electron transfe ...
in The Journal of Biological Chemistry volume 276 (2001) issue 12. - page 9253-9263
doi:10.1074/jbc.M004576200 ...

Steegborn, Clemens; Danot, Olivier; Huber, Robert; Clausen, Tim
Crystal structure of transcription factor MalT domain III : a novel helix repeat fold implicate ...
in Structure volume 9 (2001) issue 11. - page 1051-1060
doi:10.1016/S0969-2126(01)00665-7 ...

2000

Steegborn, Clemens; Schneider-Hassloff, Henriette; Zeeb, Markus; Balbach, Jochen
Cooperativity of a protein folding reaction probed at multiple chain positions by real-time 2D ...
in Biochemistry volume 39 (2000) issue 27. - page 7910-7919
doi:10.1021/bi000270u ...

Clausen, Tim; Kaiser, Jens T.; Steegborn, Clemens; Huber, Robert; Kessler, Dorothea
Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persul ...
in Proceedings of the National Academy of Sciences of the United States of America volume 97 (2000) issue 8. - page 3856-3861
doi:10.1073/pnas.97.8.3856 ...

Schreiber, Valerie; Steegborn, Clemens; Clausen, Tim; Boos, Winfried; Richet, Evelyne
A new mechanism for the control of a prokaryotic transcriptional regulator: antagonistic bindin ...
in Molecular Microbiology volume 35 (2000) issue 4. - page 765-776
doi:10.1046/j.1365-2958.2000.01747.x ...

Clausen, Tim; Schlegel, Anja; Peist, Ralf; Schneider, Eva; Steegborn, Clemens; Chang, Yuh-Shin; Haase, Andrea; Bourenkov, Gleb P.; Bartunik, Hans D.; Boos, Winfried
X-ray structure of MalY from Escherichia coli: a pyridoxal 5'-phosphate-dependent enzyme acting ...
in The EMBO Journal volume 19 (2000) issue 5. - page 831-842
doi:10.1093/emboj/19.5.831 ...

1999

Clausen, Tim; Wahl, Markus C.; Messerschmidt, Albrecht; Huber, Robert; Fuhrmann, Jens C.; Laber, Bernd; Streber, Wolfgang; Steegborn, Clemens
Cloning, purification and characterisation of cystathionine γ-Synthase from Nicotiana tabacum
in Biological Chemistry volume 380 (1999) issue 10. - page 1237-1242
doi:10.1515/BC.1999.157 ...

Steegborn, Clemens; Messerschmidt, Albrecht; Laber, Bernd; Streber, Wolfgang; Huber, Robert; Clausen, Tim
The crystal structure of cystathionine γ-synthase from Nicotiana tabacum reveals its substrate ...
in Journal of Molecular Biology volume 290 (1999) issue 5. - page 983-996
doi:10.1006/jmbi.1999.2935 ...

Balbach, Jochen; Steegborn, Clemens; Schindler, Thomas; Schmid, Franz X.
A protein folding intermediate of ribonuclease T₁ characterized at high resolution by 1D and 2D ...
in Journal of Molecular Biology volume 285 (1999) issue 2. - page 829-842
doi:10.1006/jmbi.1998.2364 ...

Steegborn, Clemens; Clausen, Tim; Sondermann, Peter; Jacob, Uwe; Worbs, Michael; Marinkovic, Snezan; Huber, Robert; Wahl, Markus C.
Kinetics and inhibition of recombinant human cystathionine gamma-lyase : Toward the rational co ...
in The Journal of Biological Chemistry volume 274 (1999) issue 18. - page 12675-12684
doi:10.1074/jbc.274.18.12675 ...

1997

Steegborn, Clemens; Skládal, Petr
Construction and characterization of the direct piezoelectric immunosensor for atrazine operati ...
in Biosensors and Bioelectronics volume 12 (1997) issue 1. - page 19-27
doi:10.1016/0956-5663(96)89086-5 ...

1996

Sprinzl, Mathias; Steegborn, Clemens; Hübel, Frank; Steinberg, Sergey
Compilation of tRNA sequences and sequences of tRNA genes.
in Nucleic Acids Research volume 24 (1996) issue 1. - page 68-72
doi:10.1093/nar/24.1.68 ...

Metzger, Armin U.; Schindler, Thomas; Willbold, Dieter; Kraft, Margot; Steegborn, Clemens; Volkmann, Andrea; Frank, Rainer W.; Rösch, Paul
Structural rearrangements on HIV-1 Tat (32-72) TAR complex formation
in FEBS Letters volume 384 (1996) issue 3. - page 255-259
doi:10.1016/0014-5793(96)00314-6 ...

Faculty of Biology, Chemistry & Earth Sciences
Chair of Biochemistry

Prof. Dr. Clemens Steegborn

Department of Chemistry

University of Bayreuth
Universitätsstrasse 30
95447 Bayreuth

Phone: +49 (0)921 / 55-2420
E-mail: clemens.steegborn@uni-bayreuth.de
Homepage: Chair of Biochemistry

Webmaster: Univ.Prof.Dr. Hans-Werner Schmidt

Prof. Dr. Clemens Steegborn

Faculty of Biology, Chemistry & Earth SciencesChair of Biochemistry

Job History

Education

Awards and other responsibilities

Faculty of Biology, Chemistry & Earth SciencesChair of Biochemistry

Faculty of Biology, Chemistry & Earth SciencesChair of Biochemistry

Selected publications

Faculty of Biology, Chemistry & Earth SciencesChair of Biochemistry

Faculty of Biology, Chemistry & Earth Sciences
Chair of Biochemistry

Faculty of Biology, Chemistry & Earth Sciences
Chair of Biochemistry

Faculty of Biology, Chemistry & Earth Sciences
Chair of Biochemistry

Faculty of Biology, Chemistry & Earth Sciences
Chair of Biochemistry